Mostrar el registro sencillo del ítem

Impact of Family Violence on Antisocial Behaviors in Two Developmental Periods: the Investigation of the Moderating Role of a Haplotypic Serotonergic Polygenic Score

dc.rights.licenseopenen_US
dc.contributor.authorLANGEVIN, Stephanie
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorBOULIANE, Mélanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
ORCID: 0000-0001-7944-0647
dc.contributor.authorTREMBLAY, Richard E.
dc.contributor.authorTURECKI, Gustavo
dc.contributor.authorVITARO, Frank
dc.contributor.authorOUELLET-MORIN, Isabelle
dc.date.accessioned2023-10-17T09:25:15Z
dc.date.available2023-10-17T09:25:15Z
dc.date.issued2023-07-26
dc.identifier.issn2199-4641en_US
dc.identifier.urioai:crossref.org:10.1007/s40865-023-00239-w
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184450
dc.description.abstractEnChildren exposed to family violence, such as child-directed and child-witnessed parental violence, tend to manifest higher levels of antisocial behaviors later in life. Genetically informed studies additionally show that antisocial behaviors are partly inherited. While there is a consensus about the polygenic nature of antisocial behavior, it remains unclear as to whether the differences present at the DNA level moderate the impact of parental violence on antisocial behaviors. This study tested whether children who were the victims of, or who witnessed, family violence exhibit more antisocial behaviors once they reach adolescence and early adulthood, and whether this risk varied according to a serotonergic polygenic index. Participants were 410 male members of the Quebec Longitudinal Study of Kindergarten Children. Child-directed and child-witnessed parental violence and participants’ antisocial behaviors were self-reported or assessed through semi-structured interviews. Previously derived haplotype-based polygenic indexes mapping to 11 serotonergic genes were used. Participants who were the victims of, or witnessed parental violence, were generally at higher risk of manifesting antisocial behaviors. Findings also offered a partial support to prior evidence for gene-environment interactions in some, but not all antisocial outcomes. Participants who were victims of child-directed parental violence and carried lower serotonergic risk were at higher risk of manifesting property or violent crimes in adulthood, supporting the Social-push model. Alternatively, participants who witnessed intra-parental violence were at higher risk of exhibiting symptoms of conduct disorder and antisocial personality disorder if they carried a higher number of haplotypic risk alleles, lending support to the Diathesis-stress model. This study extends prior work by emphasizing the need to separately investigate distinct forms of family violence and to use indicators of risk capturing variants present across multiple genes to better understand their independent and joint contributions to antisocial behaviors over the life course.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enAntisocial behaviors
dc.subject.enSerotonergic genes
dc.subject.enPolygenic score
dc.subject.enFamily violence
dc.subject.enCandidate genes
dc.subject.enGene-environment interplay (GxE)
dc.title.enImpact of Family Violence on Antisocial Behaviors in Two Developmental Periods: the Investigation of the Moderating Role of a Haplotypic Serotonergic Polygenic Score
dc.title.alternativeJ Dev Life Course Cren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s40865-023-00239-wen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalJournal of Developmental and Life-Course Criminologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHYen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04245731
hal.version1
hal.date.transferred2023-10-17T09:25:18Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Developmental%20and%20Life-Course%20Criminology&rft.date=2023-07-26&rft.eissn=2199-4641&rft.issn=2199-4641&rft.au=LANGEVIN,%20Stephanie&BOIVIN,%20Michel&BOULIANE,%20M%C3%A9lanie&COTE,%20Sylvana&TREMBLAY,%20Richard%20E.&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem