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Autophagy protein 5 controls flow-dependent endothelial functions.
dc.rights.license | open | en_US |
dc.contributor.author | NIVOIT, Pierre | |
dc.contributor.author | MATHIVET, Thomas | |
dc.contributor.author | WU, Junxi | |
dc.contributor.author | SALEMKOUR, Yann | |
dc.contributor.author | SANKAR, Devanarayanan Siva | |
dc.contributor.author | BAUDRIE, Véronique | |
dc.contributor.author | BOURREAU, Jennifer | |
dc.contributor.author | GUIHOT, Anne-Laure | |
dc.contributor.author | VESSIERES, Emilie | |
dc.contributor.author | LEMITRE, Mathilde | |
dc.contributor.author | BOCCA, Cinzia | |
hal.structure.identifier | Bordeaux Imaging Center [BIC] | |
dc.contributor.author | TEILLON, Jérémie | |
dc.contributor.author | LE GALL, Morgane | |
dc.contributor.author | CHIPONT, Anna | |
dc.contributor.author | ROBIDEL, Estelle | |
dc.contributor.author | DHAUN, Neeraj | |
dc.contributor.author | CAMERER, Eric | |
dc.contributor.author | REYNIER, Pascal | |
hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
dc.contributor.author | ROUX, Etienne | |
hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
dc.contributor.author | COUFFINHAL, Thierry | |
dc.contributor.author | HADOKE, Patrick W F | |
dc.contributor.author | SILVESTRE, Jean-Sébastien | |
dc.contributor.author | GUILLONNEAU, Xavier | |
dc.contributor.author | BONNIN, Philippe | |
dc.contributor.author | HENRION, Daniel | |
dc.contributor.author | DENGJEL, Joern | |
dc.contributor.author | THARAUX, Pierre-Louis | |
dc.contributor.author | LENOIR, Olivia | |
dc.date.accessioned | 2023-10-09T14:35:31Z | |
dc.date.available | 2023-10-09T14:35:31Z | |
dc.date.issued | 2023-07-18 | |
dc.identifier.issn | 1420-9071 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184367 | |
dc.description.abstractEn | Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where impaired flow-mediated endothelial cell responses promote cardiovascular risk. The mechanism by which the autophagy machinery regulates endothelial functions is complex. We applied multi-omics approaches and in vitro and in vivo functional assays to decipher the diverse roles of autophagy in endothelial cells. We demonstrate that autophagy regulates VEGF-dependent VEGFR signaling and VEGFR-mediated and flow-mediated eNOS activation. Endothelial ATG5 deficiency in vivo results in selective loss of flow-induced vasodilation in mesenteric arteries and kidneys and increased cerebral and renal vascular resistance in vivo. We found a crucial pathophysiological role for autophagy in endothelial cells in flow-mediated outward arterial remodeling, prevention of neointima formation following wire injury, and recovery after myocardial infarction. Together, these findings unravel a fundamental role of autophagy in endothelial function, linking cell proteostasis to mechanosensing. | |
dc.language.iso | EN | en_US |
dc.subject | Article recherche | |
dc.subject.en | Humans | |
dc.subject.en | Autophagy | |
dc.subject.en | Autophagy-Related Protein 5 | |
dc.subject.en | Endothelial Cells | |
dc.subject.en | Endothelium | |
dc.subject.en | Vascular | |
dc.subject.en | Mesenteric Arteries | |
dc.subject.en | Myocardial Infarction | |
dc.subject.en | Nitric Oxide Synthase Type III | |
dc.subject.en | Signal Transduction | |
dc.subject.en | Vasodilation | |
dc.subject.en | Animals | |
dc.subject.en | Mice | |
dc.title.en | Autophagy protein 5 controls flow-dependent endothelial functions. | |
dc.title.alternative | Cell Mol Life Sci | en_US |
dc.type | Article de revue | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
dc.identifier.pubmed | 37460898 | en_US |
bordeaux.journal | Cellular and Molecular Life Sciences | en_US |
bordeaux.page | 210 | en_US |
bordeaux.volume | 80 | en_US |
bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
bordeaux.issue | 8 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | pubmed | |
hal.identifier | hal-04233717 | |
hal.version | 1 | |
hal.date.transferred | 2023-10-09T14:35:34Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
workflow.import.source | pubmed | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cellular%20and%20Molecular%20Life%20Sciences&rft.date=2023-07-18&rft.volume=80&rft.issue=8&rft.spage=210&rft.epage=210&rft.eissn=1420-9071&rft.issn=1420-9071&rft.au=NIVOIT,%20Pierre&MATHIVET,%20Thomas&WU,%20Junxi&SALEMKOUR,%20Yann&SANKAR,%20Devanarayanan%20Siva&rft.genre=article |
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