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Contribution of alcohol use in HIV/hepatitis C virus co-infection to all-cause and cause-specific mortality: A collaboration of cohort studies.

dc.rights.licenseopenen_US
dc.contributor.authorTRICKEY, Adam
dc.contributor.authorINGLE, Suzanne M
dc.contributor.authorBOYD, Anders
dc.contributor.authorGILL, M John
dc.contributor.authorGRABAR, Sophie
dc.contributor.authorJARRIN, Inma
dc.contributor.authorOBEL, Niels
dc.contributor.authorTOULOUMI, Giota
dc.contributor.authorZANGERLE, Robert
dc.contributor.authorRAUCH, Andri
dc.contributor.authorRENTSCH, Christopher T
dc.contributor.authorSATRE, Derek D
dc.contributor.authorSILVERBERG, Michael J
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorGUEST, Jodie
dc.contributor.authorBURKHOLDER, Greer
dc.contributor.authorCRANE, Heidi
dc.contributor.authorTEIRA, Ramon
dc.contributor.authorBERENGUER, Juan
dc.contributor.authorWYEN, Christoph
dc.contributor.authorABGRALL, Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHESSAMFAR, Mojgan
dc.contributor.authorREISS, Peter
dc.contributor.authorD'ARMINIO MONFORTE, Antonella
dc.contributor.authorMCGINNIS, Kathleen A
dc.contributor.authorSTERNE, Jonathan A C
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.date.accessioned2023-10-04T14:03:22Z
dc.date.available2023-10-04T14:03:22Z
dc.date.issued2023-06-20
dc.identifier.issn1365-2893en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184324
dc.description.abstractEnAmong persons with HIV (PWH), higher alcohol use and having hepatitis C virus (HCV) are separately associated with increased morbidity and mortality. We investigated whether the association between alcohol use and mortality among PWH is modified by HCV. Data were combined from European and North American cohorts of adult PWH who started antiretroviral therapy (ART). Self-reported alcohol use data, collected in diverse ways between cohorts, were converted to grams/day. Eligible PWH started ART during 2001-2017 and were followed from ART initiation for mortality. Interactions between the associations of baseline alcohol use (0, 0.1-20.0, >20.0 g/day) and HCV status were assessed using multivariable Cox models. Of 58,769 PWH, 29,711 (51%), 23,974 (41%) and 5084 (9%) self-reported alcohol use of 0 g/day, 0.1-20.0 g/day, and > 20.0 g/day, respectively, and 4799 (8%) had HCV at baseline. There were 844 deaths in 37,729 person-years and 2755 deaths in 443,121 person-years among those with and without HCV, respectively. Among PWH without HCV, adjusted hazard ratios (aHRs) for mortality were 1.18 (95% CI: 1.08-1.29) for 0.0 g/day and 1.84 (1.62-2.09) for >20.0 g/day compared with 0.1-20.0 g/day. This J-shaped pattern was absent among those with HCV: aHRs were 1.00 (0.86-1.17) for 0.0 g/day and 1.64 (1.33-2.02) for >20.0 g/day compared with 0.1-20.0 g/day (interaction p < .001). Among PWH without HCV, mortality was higher in both non-drinkers and heavy drinkers compared with moderate alcohol drinkers. Among those with HCV, mortality was higher in heavy drinkers but not non-drinkers, potentially due to differing reasons for not drinking (e.g. illness) between those with and without HCV.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAdult
dc.subject.enHumans
dc.subject.enHepacivirus
dc.subject.enCause of Death
dc.subject.enCoinfection
dc.subject.enHepatitis C
dc.subject.enCohort Studies
dc.subject.enHIV Infections
dc.title.enContribution of alcohol use in HIV/hepatitis C virus co-infection to all-cause and cause-specific mortality: A collaboration of cohort studies.
dc.title.alternativeJ Viral Hepaten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/jvh.13863en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37338017en_US
bordeaux.journalJournal of Viral Hepatitisen_US
bordeaux.page775-786en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamGHIGSen_US
bordeaux.teamSISTMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
bordeaux.identifier.funderIDMinistère de la Santéen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Viral%20Hepatitis&amp;rft.date=2023-06-20&amp;rft.volume=30&amp;rft.issue=9&amp;rft.spage=775-786&amp;rft.epage=775-786&amp;rft.eissn=1365-2893&amp;rft.issn=1365-2893&amp;rft.au=TRICKEY,%20Adam&amp;INGLE,%20Suzanne%20M&amp;BOYD,%20Anders&amp;GILL,%20M%20John&amp;GRABAR,%20Sophie&amp;rft.genre=article


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