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Correlation of nailfold capillaroscopy findings with history of digital ulcer on same finger: Results of SCLEROCAP study

dc.rights.licenseopenen_US
dc.contributor.authorBOULON, Carine
dc.contributor.authorVELARDO, Fanny
dc.contributor.authorBLAISE, Sophie
dc.contributor.authorMANGIN, Marion
dc.contributor.authorDECAMPS-LE CHEVOIR, Joelle
dc.contributor.authorSENET, Patricia
dc.contributor.authorLAZARETH, Isabelle
dc.contributor.authorBAUDOT, Nathalie
dc.contributor.authorTRIBOUT, Laurent
dc.contributor.authorIMBERT, Bernard
dc.contributor.authorLAPEBIE, Francois-Xavier
dc.contributor.authorDARI, Loubna
dc.contributor.authorLACROIX, Philippe
dc.contributor.authorTRUCHETET, Marie-Elise
dc.contributor.authorSENESCHAL, Julien
dc.contributor.authorSOLANILLA, Anne
dc.contributor.authorLAZARO, Estibaliz
dc.contributor.authorQUERE, Isabelle
dc.contributor.authorPISTORIUS, Marc-Antoine
dc.contributor.authorASSELINEAU, Julien
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
dc.contributor.authorLHOMME, Edouard
dc.contributor.authorCARPENTIER, Patrick
dc.contributor.authorCONSTANS, Joel
dc.date.accessioned2023-06-29T09:55:32Z
dc.date.available2023-06-29T09:55:32Z
dc.date.issued2022-03-31
dc.identifier.issn1095-9319 (Electronic) 0026-2862 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183242
dc.description.abstractEnSystemic sclerosis may be complicated by digital ulcers. Nailfold capillaroscopy on one finger might reflect an increased risk of digital ulcer (DU). In the present study we studied the correlations between a history of ulcer and capillary findings on the finger. METHOD: This study is part of Sclerocap, a multicenter study aiming at validating prospectively the prognostic value of Maricq's and Cutolo's capillaroscopic classifications during a three-year longitudinal follow-up. A history of past or present digital ulcer was recorded at inclusion and nailfold capillaroscopy was performed. Elementary findings as well as Cutolo and Maricq's classifications were assessed. RESULTS: 387 patients were included in Sclerocap (327 females, 60 males) and 3096 fingers were examined by capillaroscopy at inclusion: 316 fingers (10%) belonging to 113 patients had a history of DU. Late Cutolo's stage was statistically correlated with a history of DU, both by univariate: OR 2.08 [1.09-3.96] and multivariate analysis: OR 1.97 [1.06-3.63]. Among the elemental abnormalities, only edema and decreased capillary density were correlated with a history of DU by multivariate analysis: respectively OR 1.92 [1.17-3.16] and 0.65 [0.49-0.85]. CONCLUSION: This cross-sectional study in a large cohort of patients with systemic sclerosis shows a correlation between a history of digital ulcer and edema, a decrease in capillary density and the late stage in Cutolo's classification. The extent of capillary abnormalities on one finger is associated with a history of local digital ulcer. Capillaroscopy might be used to predict the risk of DU but these results need first to be confirmed by prospective studies.
dc.language.isoENen_US
dc.title.enCorrelation of nailfold capillaroscopy findings with history of digital ulcer on same finger: Results of SCLEROCAP study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.mvr.2022.104365en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35367233en_US
bordeaux.journalMicrovascular Researchen_US
bordeaux.volume142en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.teamUSMRen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Microvascular%20Research&rft.date=2022-03-31&rft.volume=142&rft.eissn=1095-9319%20(Electronic)%200026-2862%20(Linking)&rft.issn=1095-9319%20(Electronic)%200026-2862%20(Linking)&rft.au=BOULON,%20Carine&VELARDO,%20Fanny&BLAISE,%20Sophie&MANGIN,%20Marion&DECAMPS-LE%20CHEVOIR,%20Joelle&rft.genre=article


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