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Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

dc.rights.licenseopenen_US
dc.contributor.authorMARLIN, Romain
dc.contributor.authorGODOT, Veronique
dc.contributor.authorCARDINAUD, Sylvain
dc.contributor.authorGALHAUT, Mathilde
dc.contributor.authorCOLEON, Severin
dc.contributor.authorZURAWSKI, Sandra
dc.contributor.authorDEREUDDRE-BOSQUET, Nathalie
dc.contributor.authorCAVARELLI, Mariangela
dc.contributor.authorGALLOUET, Anne Sophie
dc.contributor.authorMAISONNASSE, Pauline
dc.contributor.authorDUPATY, Lea
dc.contributor.authorFENWICK, Craig
dc.contributor.authorNANINCK, Thibaut
dc.contributor.authorLEMAITRE, Julien
dc.contributor.authorGOMEZ-PACHECO, Mario
dc.contributor.authorKAHLAOUI, Nidhal
dc.contributor.authorCONTRERAS, Vanessa
dc.contributor.authorRELOUZAT, Francis
dc.contributor.authorFANG, Raphael Ho Tsong
dc.contributor.authorWANG, Zhiqing
dc.contributor.authorELLIS, Jerome 3rd
dc.contributor.authorCHAPON, Catherine
dc.contributor.authorCENTLIVRE, Mireille
dc.contributor.authorWIEDEMANN, Aurelie
dc.contributor.authorLACABARATZ, Christine
dc.contributor.authorSURENAUD, Mathieu
dc.contributor.authorSZURGOT, Inga
dc.contributor.authorLILJESTROM, Peter
dc.contributor.authorPLANAS, Delphine
dc.contributor.authorBRUEL, Timothee
dc.contributor.authorSCHWARTZ, Olivier
dc.contributor.authorVAN DER WERF, Sylvie
dc.contributor.authorPANTALEO, Giuseppe
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPRAGUE, Melanie
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorZURAWSKI, Gerard
dc.contributor.authorLEVY, Yves
dc.contributor.authorLE GRAND, Roger
dc.date.accessioned2023-06-26T14:49:43Z
dc.date.available2023-06-26T14:49:43Z
dc.date.issued2021-09-01
dc.identifier.issn2041-1723 (Electronic) 2041-1723 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182837
dc.description.abstractEnAchieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (alphaCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. Additionally, we demonstrate that a single dose of the alphaCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. Vaccine-elicited antibodies cross-neutralize different SARS-CoV-2 variants, including D614G, B1.1.7 and to a lesser extent B1.351. Such vaccination significantly improves protection against a new high-dose virulent challenge versus that in non-vaccinated convalescent animals.
dc.description.sponsorshipInitiative for the creation of a Vaccine Research Instituteen_US
dc.description.sponsorshipDéveloppement de vaccins anti-SARS-CoV-2en_US
dc.description.sponsorshipInfrastructure nationale pour la modélisation des maladies infectieuses humainesen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enTargeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-021-25382-0en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34471122en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page5215en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2021-09-01&rft.volume=12&rft.issue=1&rft.spage=5215&rft.epage=5215&rft.eissn=2041-1723%20(Electronic)%202041-1723%20(Linking)&rft.issn=2041-1723%20(Electronic)%202041-1723%20(Linking)&rft.au=MARLIN,%20Romain&GODOT,%20Veronique&CARDINAUD,%20Sylvain&GALHAUT,%20Mathilde&COLEON,%20Severin&rft.genre=article


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