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Impact of Hepatitis C cure on risk of mortality and morbidity in people with HIV after ART initiation

dc.rights.licenseopenen_US
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHALOUNI, Mathieu
dc.contributor.authorTRICKEY, Adam
dc.contributor.authorINGLE, Suzanne M.
dc.contributor.authorSEPUVELDA, Maria Antonia
dc.contributor.authorGONZALEZ, Juan
dc.contributor.authorRAUCH, Andri
dc.contributor.authorCRANE, Heidi M.
dc.contributor.authorGILL, M. John
dc.contributor.authorREBEIRO, Peter F.
dc.contributor.authorROCKSTROH, Jurgen K.
dc.contributor.authorFRANCO, Ricardo A.
dc.contributor.authorTOULOUMI, Giota
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNEAU, Didier
dc.contributor.authorLAGUNO, Montserrat
dc.contributor.authorRAPPOLD, Michaela
dc.contributor.authorSMIT, Colette
dc.contributor.authorSTERNE, Jonathan Ac
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.date.accessioned2023-06-23T12:39:03Z
dc.date.available2023-06-23T12:39:03Z
dc.date.issued2023-05-10
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182784
dc.description.abstractEnOBJECTIVE: Hepatitis C Virus (HCV) co-infection is associated with increased morbidity and mortality in people with HIV (PWH). Sustained virological response (SVR) decreases the risk of HCV-associated morbidity. We compared mortality, risk of AIDS-defining events, and non-AIDS non-liver (NANL) cancers between HCV co-infected PWH who reached SVR and mono-infected PWH. DESIGN: Adult PWH from 21 cohorts in Europe and North America that collected HCV treatment data were eligible if they were HCV-free at time of ART initiation. METHODS: Up to 10 mono-infected PWH were matched (on age, sex, date of ART start, HIV acquisition route, and being followed at the time of SVR) to each HCV co-infected PWH who reached SVR. Cox models were used to estimate relative hazards (HR) of all-cause mortality, AIDS-defining events, and NANL cancers after adjustment. RESULTS: Among 62,495 PWH, 2,756 acquired HCV, of whom 649 reached SVR. For 582 of these, ≥1 mono-infected PWH could be matched, producing a total of 5,062 mono-infected PWH. The estimated HRs comparing HCV co-infected PWH who reached SVR with mono-infected PWH were 0.29 [95%CI 0.12-0.73] for mortality, 0.85 [0.42-1.74] for AIDS-defining events, and 1.21 [0.86-1.72] for NANL cancer. CONCLUSION: PWH who reached SVR a short time after HCV acquisition were not at higher risk of overall mortality compared to mono-infected PWH. However, the apparent higher risk of NANL cancers in HCV co-infected PWH who reached SVR after a DAA-based treatment compared to mono-infected PWH, though compatible with a null association, suggests a need for monitoring of those events following SVR.
dc.language.isoENen_US
dc.subject.enAIDS defining events
dc.subject.enHIV infection
dc.subject.enMortality
dc.subject.enNon-AIDS non-liver cancer
dc.subject.enSustained virological response
dc.title.enImpact of Hepatitis C cure on risk of mortality and morbidity in people with HIV after ART initiation
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000003594en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37199601en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04139288
hal.version1
hal.date.transferred2023-06-23T12:39:20Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&rft.date=2023-05-10&rft.eissn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.issn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.au=CHALOUNI,%20Mathieu&TRICKEY,%20Adam&INGLE,%20Suzanne%20M.&SEPUVELDA,%20Maria%20Antonia&GONZALEZ,%20Juan&rft.genre=article


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