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Impact of Hepatitis C cure on risk of mortality and morbidity in people with HIV after ART initiation
dc.rights.license | open | en_US |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | CHALOUNI, Mathieu | |
dc.contributor.author | TRICKEY, Adam | |
dc.contributor.author | INGLE, Suzanne M. | |
dc.contributor.author | SEPUVELDA, Maria Antonia | |
dc.contributor.author | GONZALEZ, Juan | |
dc.contributor.author | RAUCH, Andri | |
dc.contributor.author | CRANE, Heidi M. | |
dc.contributor.author | GILL, M. John | |
dc.contributor.author | REBEIRO, Peter F. | |
dc.contributor.author | ROCKSTROH, Jurgen K. | |
dc.contributor.author | FRANCO, Ricardo A. | |
dc.contributor.author | TOULOUMI, Giota | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | NEAU, Didier | |
dc.contributor.author | LAGUNO, Montserrat | |
dc.contributor.author | RAPPOLD, Michaela | |
dc.contributor.author | SMIT, Colette | |
dc.contributor.author | STERNE, Jonathan Ac | |
hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | WITTKOP, Linda | |
dc.date.accessioned | 2023-06-23T12:39:03Z | |
dc.date.available | 2023-06-23T12:39:03Z | |
dc.date.issued | 2023-05-10 | |
dc.identifier.issn | 1473-5571 (Electronic) 0269-9370 (Linking) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182784 | |
dc.description.abstractEn | OBJECTIVE: Hepatitis C Virus (HCV) co-infection is associated with increased morbidity and mortality in people with HIV (PWH). Sustained virological response (SVR) decreases the risk of HCV-associated morbidity. We compared mortality, risk of AIDS-defining events, and non-AIDS non-liver (NANL) cancers between HCV co-infected PWH who reached SVR and mono-infected PWH. DESIGN: Adult PWH from 21 cohorts in Europe and North America that collected HCV treatment data were eligible if they were HCV-free at time of ART initiation. METHODS: Up to 10 mono-infected PWH were matched (on age, sex, date of ART start, HIV acquisition route, and being followed at the time of SVR) to each HCV co-infected PWH who reached SVR. Cox models were used to estimate relative hazards (HR) of all-cause mortality, AIDS-defining events, and NANL cancers after adjustment. RESULTS: Among 62,495 PWH, 2,756 acquired HCV, of whom 649 reached SVR. For 582 of these, ≥1 mono-infected PWH could be matched, producing a total of 5,062 mono-infected PWH. The estimated HRs comparing HCV co-infected PWH who reached SVR with mono-infected PWH were 0.29 [95%CI 0.12-0.73] for mortality, 0.85 [0.42-1.74] for AIDS-defining events, and 1.21 [0.86-1.72] for NANL cancer. CONCLUSION: PWH who reached SVR a short time after HCV acquisition were not at higher risk of overall mortality compared to mono-infected PWH. However, the apparent higher risk of NANL cancers in HCV co-infected PWH who reached SVR after a DAA-based treatment compared to mono-infected PWH, though compatible with a null association, suggests a need for monitoring of those events following SVR. | |
dc.language.iso | EN | en_US |
dc.subject.en | AIDS defining events | |
dc.subject.en | HIV infection | |
dc.subject.en | Mortality | |
dc.subject.en | Non-AIDS non-liver cancer | |
dc.subject.en | Sustained virological response | |
dc.title.en | Impact of Hepatitis C cure on risk of mortality and morbidity in people with HIV after ART initiation | |
dc.title.alternative | AIDS | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1097/qad.0000000000003594 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 37199601 | en_US |
bordeaux.journal | AIDS. Official journal of the international AIDS Society | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | SISTM_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-04139288 | |
hal.version | 1 | |
hal.date.transferred | 2023-06-23T12:39:20Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&rft.date=2023-05-10&rft.eissn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.issn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.au=CHALOUNI,%20Mathieu&TRICKEY,%20Adam&INGLE,%20Suzanne%20M.&SEPUVELDA,%20Maria%20Antonia&GONZALEZ,%20Juan&rft.genre=article |
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