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Associations of longitudinal height and weight with clinical outcomes in pediatric kidney replacement therapy: results from the ESPN/ERA Registry

dc.rights.licenseopenen_US
dc.contributor.authorBONTHUIS, Marjolein
dc.contributor.authorBAKKALOGLU, Sevcan A.
dc.contributor.authorVIDAL, Enrico
dc.contributor.authorBAIKO, Sergey
dc.contributor.authorBRADDON, Fiona
dc.contributor.authorERRICHIELLO, Carmela
dc.contributor.authorFRANCISCO, Telma
dc.contributor.authorHAFFNER, Dieter
dc.contributor.authorLAHOCHE, Annie
dc.contributor.authorLESZCZYNSKA, Beata
dc.contributor.authorMASALKIENE, Jurate
dc.contributor.authorSTOJANOVIC, Jelena
dc.contributor.authorMOLCHANOVA, Maria S.
dc.contributor.authorREUSZ, George
dc.contributor.authorBARBA, Adela Rodriguez
dc.contributor.authorROSALES, Alejandra
dc.contributor.authorTEGELTIJA, Sanja
dc.contributor.authorYLINEN, Elisa
dc.contributor.authorZLATANOVA, Galia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
IDREF: 110567358
dc.contributor.authorJAGER, Kitty J.
dc.date.accessioned2023-06-21T11:04:29Z
dc.date.available2023-06-21T11:04:29Z
dc.date.issued2023-05-08
dc.identifier.issn1432-198X (Electronic) 0931-041X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182735
dc.description.abstractEnBACKGROUND: Associations between anthropometric measures and patient outcomes in children are inconsistent and mainly based on data at kidney replacement therapy (KRT) initiation. We studied associations of height and body mass index (BMI) with access to kidney transplantation, graft failure, and death during childhood KRT. METHODS: We included patients < 20 years starting KRT in 33 European countries from 1995-2019 with height and weight data recorded to the ESPN/ERA Registry. We defined short stature as height standard deviation scores (SDS) < -1.88 and tall stature as height SDS > 1.88. Underweight, overweight and obesity were calculated using age and sex-specific BMI for height-age criteria. Associations with outcomes were assessed using multivariable Cox models with time-dependent covariates. RESULTS: We included 11,873 patients. Likelihood of transplantation was lower for short (aHR: 0.82, 95% CI: 0.78-0.86), tall (aHR: 0.65, 95% CI: 0.56-0.75), and underweight patients (aHR: 0.79, 95%CI: 0.71-0.87). Compared with normal height, patients with short and tall statures showed higher graft failure risk. All-cause mortality risk was higher in short (aHR: 2.30, 95% CI: 1.92-2.74), but not in tall stature. Underweight (aHR: 1.76, 95% CI: 1.38-2.23) and obese (aHR: 1.49, 95% CI: 1.11-1.99) patients showed higher all-cause mortality risk than normal weight subjects. CONCLUSIONS: Short and tall stature and being underweight were associated with a lower likelihood of receiving a kidney allograft. Mortality risk was higher among pediatric KRT patients with a short stature or those being underweight or obese. Our results highlight the need for careful nutritional management and multidisciplinary approach for these patients. A higher resolution version of the Graphical abstract is available as Supplementary information.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enGrowth
dc.subject.enBody composition
dc.subject.enMortality
dc.subject.enKidney transplantation
dc.subject.enChildren
dc.title.enAssociations of longitudinal height and weight with clinical outcomes in pediatric kidney replacement therapy: results from the ESPN/ERA Registry
dc.title.alternativePediatr Nephrolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00467-023-05973-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37154961en_US
bordeaux.journalPediatric Nephrologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04136043
hal.version1
hal.date.transferred2023-06-21T11:05:03Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Pediatric%20Nephrology&amp;rft.date=2023-05-08&amp;rft.eissn=1432-198X%20(Electronic)%200931-041X%20(Linking)&amp;rft.issn=1432-198X%20(Electronic)%200931-041X%20(Linking)&amp;rft.au=BONTHUIS,%20Marjolein&amp;BAKKALOGLU,%20Sevcan%20A.&amp;VIDAL,%20Enrico&amp;BAIKO,%20Sergey&amp;BRADDON,%20Fiona&amp;rft.genre=article


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