Association of Physical Activity and Parkinson Disease in Women: Long-term Follow-up of the E3N Cohort Study
| dc.rights.license | open | en_US |
| dc.contributor.author | PORTUGAL, Berta | |
| dc.contributor.author | ARTAUD, Fanny | |
| dc.contributor.author | DEGAEY, Isabelle | |
| dc.contributor.author | ROZE, Emmanuel | |
| dc.contributor.author | FOURNIER, Agnes | |
| dc.contributor.author | SEVERI, Gianluca | |
| dc.contributor.author | CANONICO, Marianne | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile | |
| dc.contributor.author | ELBAZ, Alexis | |
| dc.date.accessioned | 2023-06-21T09:21:43Z | |
| dc.date.available | 2023-06-21T09:21:43Z | |
| dc.date.issued | 2023-05-17 | |
| dc.identifier.issn | 1526-632X (Electronic) 0028-3878 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182731 | |
| dc.description.abstractEn | BACKGROUND AND OBJECTIVES: Previous cohort studies reported that a single measure of physical activity (PA) assessed at baseline was associated with lower Parkinson's disease (PD) incidence, but a meta-analysis suggested that this association was restricted to men. Due to the long prodromal phase of the disease, reverse causation could not be excluded as a potential explanation. Our objective was to study the association between time-varying PA and PD using lagged analyses to address the potential for reverse causation, and to compare PA trajectories in patients prior to diagnosis and matched controls. METHODS: We used data from E3N (1990-2018), a cohort study of women affiliated with a national health insurance plan for persons working in education. PA was self-reported in six questionnaires over the follow-up. As questions changed across questionnaires, we created a time-varying latent PA (LPA) variable using latent-process mixed models. PD was ascertained using a multistep validation process based on medical records, or a validated algorithm based on drug claims. We set-up a nested case-control study to examine differences in LPA trajectories using multivariable linear mixed models with a retrospective time scale. Cox proportional hazards models with age as the timescale and adjusted for confounders were used to estimate the association between time-varying LPA and PD incidence. Our main analysis used a 10y-lag to account for reverse causation; sensitivity analyses used 5y, 15y, and 20y-lags. RESULTS: Analyses of trajectories (1,196 cases, 23,879 controls) showed that LPA was significantly lower in cases than in controls throughout the follow-up, including 29y before diagnosis; the difference between cases and controls started to increase ∼10y before diagnosis (P-interaction=0.003). In our main survival analysis, of 95,354 women free of PD in 2000, 1,074 women developed PD over a mean follow-up of 17.2y. PD incidence decreased with increasing LPA (P-trend=0.001), with 25% lower incidence in those in the highest quartile compared to the lowest (adjusted hazard ratio=0.75, 95% confidence interval=0.63-0.89). Using longer lags yielded similar conclusions. DISCUSSION: Higher PA level is associated with lower PD incidence in women, not explained by reverse causation. These results are important for planning interventions for PD prevention. | |
| dc.description.sponsorship | Etude Epidémiologique des Enfants de femmes de l'Education Nationale - ANR-10-COHO-0006 | en_US |
| dc.description.sponsorship | Facteurs de risque de la Maladie de Parkinson chez les femmes de la cohorte E3N - ANR-18-CE36-0006 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.title.en | Association of Physical Activity and Parkinson Disease in Women: Long-term Follow-up of the E3N Cohort Study | |
| dc.title.alternative | Neurology | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1212/wnl.0000000000207424 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37197993 | en_US |
| bordeaux.journal | Neurology | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04135800 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-06-21T09:21:46Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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