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dc.rights.licenseopenen_US
dc.contributor.authorDRUMMEN, Mathijs
dc.contributor.authorTISCHMANN, Lea
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGATTA-CHERIFI, Blandine
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMATIAS, Isabelle
hal.structure.identifierUniversity of Copenhagen
dc.contributor.authorRABEN, Anne
dc.contributor.authorADAM, Tanja
dc.contributor.authorWESTERTERP-PLANTENGA, Margriet S.
dc.date.accessioned2023-06-19T08:47:40Z
dc.date.available2023-06-19T08:47:40Z
dc.date.issued2020-07-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182715
dc.description.abstractEnContext: Endocannabinoids are suggested to play a role in energy balance regulation. Objective: We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the postobese phase with prediabetes. Design and Participants: Participants (n = 38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber. Main Outcome Measures: Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed. Results: Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to body mass index (AEA) or body fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. Area under the curve (AUC) of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body fat% (P < .05). The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs the MP group. Conclusions: In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, whereas the endocannabinoid AEA and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure during the day. © 2020 Endocrine Society. All rights reserved.
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.subject.enEndocannabinoids
dc.subject.enEnergy balance
dc.subject.enAdiposity
dc.subject.enProtein
dc.title.enRole of endocannabinoids in energy-balance regulation in participants in the postobese state - A PREVIEW study
dc.title.alternativeJ Clin Endocrinol Metaben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1210/clinem/dgaa193en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32333763en_US
dc.description.sponsorshipEuropeEU Framework Programme Horizon 2020en_US
bordeaux.journalJournal of Clinical Endocrinology and Metabolismen_US
bordeaux.volume105en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04132470
hal.version1
hal.date.transferred2023-06-19T08:47:49Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Clinical%20Endocrinology%20and%20Metabolism&amp;rft.date=2020-07-01&amp;rft.volume=105&amp;rft.issue=7&amp;rft.au=DRUMMEN,%20Mathijs&amp;TISCHMANN,%20Lea&amp;GATTA-CHERIFI,%20Blandine&amp;COTA,%20Daniela&amp;MATIAS,%20Isabelle&amp;rft.genre=article


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