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Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study

hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorENAUD, Raphaël
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorCAMBOS, Sophie
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorVIAUD, Esther
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorGUICHOUX, Erwan
hal.structure.identifierBiodiversité, Gènes & Communautés [BioGeCo]
dc.contributor.authorCHANCEREL, Emilie
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorMARIGHETTO, Aline
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorETCHAMENDY, Nicole
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorCLARK, Samantha
hal.structure.identifierCHU Bordeaux
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorCOTA, Daniela
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorDELHAES, Laurence
hal.structure.identifierCHU Bordeaux
hal.structure.identifierPhysiopathologie du système nerveux central - Institut François Magendie
dc.contributor.authorGATTA-CHERIFI, Blandine
dc.date.issued2021-11
dc.identifier.issn2072-6643
dc.description.abstractEnPatients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated association between changes of gut microbiota and cognitive function after BS. We prospectively evaluated 13 obese patients on anthropometric data, memory functions, and gut microbiota-mycobiota before and six months after BS. The Rey Auditory Verbal Learning Test (AVLT) and the symbol span (SS) of the Weschler Memory Scale were used to assess verbal and working memory, respectively. Fecal microbiota and mycobiota were longitudinally analyzed by 16S and ITS2 rRNA sequencing respectively. AVLT and SS scores were significantly improved after BS (AVLT scores: 9.7 ± 1.7 vs. 11.2 ± 1.9, p = 0.02, and SS scores: 9.7 ± 23.0 vs. 11.6 ± 2.9, p = 0.05). An increase in bacterial alpha-diversity, and Ruminococcaceae, Prevotella, Agaricus, Rhodotorula, Dipodascus, Malassezia, and Mucor were significantly associated with AVLT score improvement after BS, while an increase in Prevotella and a decrease in Clostridium, Akkermansia, Dipodascus and Candida were linked to SS scores improvement. We identified several changes in the microbial communities that differ according to the improvement of either the verbal or working memories, suggesting a complex gut-brain-axis that evolves after BS.
dc.language.isoen
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.subject.enmetagenomics
dc.subject.enmicrobiome
dc.subject.enmicrobiota
dc.subject.enmycobiota
dc.subject.enobesity
dc.subject.enbariatric surgery
dc.title.enGut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study
dc.typeArticle de revue
dc.identifier.doi10.3390/nu13114061
dc.subject.halSciences de l'environnement
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalNutrients
bordeaux.page4061
bordeaux.volume13
bordeaux.issue11
bordeaux.peerReviewedoui
hal.identifierhal-04123512
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04123512v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.date=2021-11&rft.volume=13&rft.issue=11&rft.spage=4061&rft.epage=4061&rft.eissn=2072-6643&rft.issn=2072-6643&rft.au=ENAUD,%20Rapha%C3%ABl&CAMBOS,%20Sophie&VIAUD,%20Esther&GUICHOUX,%20Erwan&CHANCEREL,%20Emilie&rft.genre=article


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