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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMUNSCH, Gaelle
dc.contributor.authorGOUMIDI, Louisa
dc.contributor.authorVAN HYLCKAMA VLIEG, Astrid
dc.contributor.authorIBRAHIM-KOSTA, Manal
dc.contributor.authorBRUZELIUS, Maria
dc.contributor.authorDELEUZE, Jean-Francois
dc.contributor.authorROSENDAAL, Frits R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJACQMIN-GADDA, Helene
dc.contributor.authorMORANGE, Pierre-Emmanuel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.date.accessioned2023-05-15T09:36:39Z
dc.date.available2023-05-15T09:36:39Z
dc.date.issued2023-04-22
dc.identifier.issn1471-2288 (Electronic) 1471-2288 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182119
dc.description.abstractEnBACKGROUND: In studies of time-to-events, it is common to collect information about events that occurred before the inclusion in a prospective cohort. When the studied risk factors are independent of time, including both pre- and post-inclusion events in the analyses, generally referred to as relying on an ambispective design, increases the statistical power but may lead to a selection bias. In the field of venous thromboembolism (VT), ABO blood groups have been the subject of extensive research due to their substantial effect on VT risk. However, few studies have investigated their effect on the risk of VT recurrence. Motivated by the study of the association of genetically determined ABO blood groups with VT recurrence, we propose a methodology to include pre-inclusion events in the analysis of ambispective studies while avoiding the selection bias due to mortality. METHODS: This work relies on two independent cohorts of VT patients, the French MARTHA study built on an ambispective design and the Dutch MEGA study built on a standard prospective design. For the analysis of the MARTHA study, a weighted Cox model was developed where weights were defined by the inverse of the survival probability at the time of data collection about the events. Thanks to the collection of information on the vital status of patients, we could estimate the survival probabilities using a delayed-entry Cox model on the death risk. Finally, results obtained in both studies were then meta-analysed. RESULTS: In the combined sample totalling 2,752 patients including 993 recurrences, the A1 blood group has an increased risk (Hazard Ratio (HR) of 1.18, p = 4.2 × 10(-3)) compared with the O1 group, homogeneously in MARTHA and in MEGA. The same trend (HR = 1.19, p = 0.06) was observed for the less frequent A2 group. CONCLUSION: The proposed methodology increases the power of studies relying on an ambispective design which is frequent in epidemiologic studies about recurrent events. This approach allowed to clarify the association of ABO blood groups with the risk of VT recurrence. Besides, this methodology has an immediate field of application in the context of genome wide association studies.
dc.description.sponsorshipMedical Genomics - ANR-10-LABX-0013en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAmbispective design
dc.subject.enSurvival analysis
dc.subject.enVenous thrombosis
dc.subject.enRecurrence
dc.subject.enABO blood groups
dc.subject.enGenetic association studies
dc.title.enAssociation of ABO blood groups with venous thrombosis recurrence in middle-aged patients: insights from a weighted Cox analysis dedicated to ambispective design
dc.title.alternativeBMC Med Res Methodolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12874-023-01915-7en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37087423en_US
bordeaux.journalBMC Medical Research Methodologyen_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04097426
hal.version1
hal.date.transferred2023-05-15T09:36:43Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Medical%20Research%20Methodology&rft.date=2023-04-22&rft.volume=23&rft.issue=1&rft.eissn=1471-2288%20(Electronic)%201471-2288%20(Linking)&rft.issn=1471-2288%20(Electronic)%201471-2288%20(Linking)&rft.au=MUNSCH,%20Gaelle&GOUMIDI,%20Louisa&VAN%20HYLCKAMA%20VLIEG,%20Astrid&IBRAHIM-KOSTA,%20Manal&BRUZELIUS,%20Maria&rft.genre=article


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