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Role of mechanical cues and hypoxia on the growth of tumor cells in strong and weak confinement: A dual in vitro–in silico approach

hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorLE MAOUT, V.
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorALESSANDRI, K.
hal.structure.identifierSorbonne Université [SU]
hal.structure.identifierInstitut du Cerveau = Paris Brain Institute [ICM]
dc.contributor.authorGURCHENKOV, B.
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorBERTIN, H.
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorNASSOY, P.
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorSCIUMÉ, G.
dc.date.accessioned2023-05-12T10:41:33Z
dc.date.available2023-05-12T10:41:33Z
dc.date.issued2020-03-25
dc.identifier.issn2375-2548
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181621
dc.description.abstractEnCharacterization of tumor growth dynamics is of major importance for cancer understanding. By contrast with phenomenological approaches, mechanistic modeling can facilitate disclosing underlying tumor mechanisms and lead to identification of physical factors affecting proliferation and invasive behavior. Current mathematical models are often formulated at the tissue or organ scale with the scope of a direct clinical usefulness. Consequently, these approaches remain empirical and do not allow gaining insight into the tumor properties at the scale of small cell aggregates. Here, experimental and numerical studies of the dynamics of tumor aggregates are performed to propose a physics-based mathematical model as a general framework to investigate tumor microenvironment. The quantitative data extracted from the cellular capsule technology microfluidic experiments allow a thorough quantitative comparison with in silico experiments. This dual approach demonstrates the relative impact of oxygen and external mechanical forces during the time course of tumor model progression.
dc.description.sponsorshipNouvelles voies de formation de vaisseaux sanguins et lymphatiques: Development d'un système d'encapsulation et l'etude de l'impact des forces mécaniques sur les mécanismes de régulation cellulaires et moléculaires - ANR-15-CE18-0019
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.rights.urihttp://creativecommons.org/licenses/by-nc/
dc.title.enRole of mechanical cues and hypoxia on the growth of tumor cells in strong and weak confinement: A dual in vitro–in silico approach
dc.typeArticle de revue
dc.identifier.doi10.1126/sciadv.aaz7130
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalScience Advances
bordeaux.pageeaaz7130
bordeaux.volume6
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.issue13
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-02552525
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02552525v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Advances&rft.date=2020-03-25&rft.volume=6&rft.issue=13&rft.spage=eaaz7130&rft.epage=eaaz7130&rft.eissn=2375-2548&rft.issn=2375-2548&rft.au=LE%20MAOUT,%20V.&ALESSANDRI,%20K.&GURCHENKOV,%20B.&BERTIN,%20H.&NASSOY,%20P.&rft.genre=article


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