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Unexpected Membrane Dynamics Unveiled by Membrane Nanotube Extrusion

hal.structure.identifierStructures et propriétés d'architectures moléculaire [SPRAM - UMR 5819]
hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorCAMPILLO, Clément
hal.structure.identifierLaboratoire de Physico-Chimie Théorique [LPCT]
dc.contributor.authorSENS, Pierre
hal.structure.identifierPhysico-Chimie-Curie [PCC]
hal.structure.identifierNational Centre for Biological Sciences [NCBS]
dc.contributor.authorKOESTER, Darius
hal.structure.identifierPhysico-Chimie-Curie [PCC]
hal.structure.identifierNYU Center of Soft Matter Research
dc.contributor.authorPONTANI, Lea-Laetitia
hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorLÉVY, Daniel
hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorBASSEREAU, Patricia
hal.structure.identifierlp2n-04,lp2n-16
hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorNASSOY, Pierre
hal.structure.identifierPhysico-Chimie-Curie [PCC]
dc.contributor.authorSYKES, C.
dc.date.accessioned2023-05-12T10:22:45Z
dc.date.available2023-05-12T10:22:45Z
dc.date.created2012-09-05
dc.date.issued2013-03-19
dc.identifier.issn0006-3495
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/181154
dc.description.abstractEnIn cell mechanics, distinguishing the respective roles of the plasma membrane and of the cytoskeleton is a challenge. The difference in the behavior of cellular and pure lipid membranes is usually attributed to the presence of the cytoskeleton as explored by membrane nanotube extrusion. Here we revisit this prevalent picture by unveiling unexpected force responses of plasma membrane spheres devoid of cytoskeleton and synthetic liposomes. We show that a tiny variation in the content of synthetic membranes does not affect their static mechanical properties, but is enough to reproduce the dynamic behavior of their cellular counterparts. This effect is attributed to an amplified intramembrane friction. Reconstituted actin cortices inside liposomes induce an additional, but not dominant, contribution to the effective membrane friction. Our work underlines the necessity of a careful consideration of the role of membrane proteins on cell membrane rheology in addition to the role of the cytoskeleton.
dc.language.isoen
dc.publisherBiophysical Society
dc.subject.enBLOOD-CELL MEMBRANE
dc.subject.enBILAYER-MEMBRANES
dc.subject.enTETHER FORMATION
dc.subject.enMECHANICAL-PROPERTIES
dc.subject.enERYTHROCYTE-MEMBRANE
dc.subject.enCORTICAL TENSION
dc.subject.enEXTENSIONAL FLOW
dc.subject.enPLASMA-MEMBRANE
dc.subject.enELASTIC TETHER
dc.subject.enACTIN CORTEX
dc.title.enUnexpected Membrane Dynamics Unveiled by Membrane Nanotube Extrusion
dc.typeArticle de revue
dc.identifier.doi10.1016/j.bpj.2013.01.051
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalBiophysical Journal
bordeaux.page1248-1256
bordeaux.volume104
bordeaux.hal.laboratoriesLaboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298*
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00821323
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00821323v1
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