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dc.rights.licenseopenen_US
dc.contributor.authorEL-OUSSINI, Hajer
dc.contributor.authorZHANG, Chun-Lei
dc.contributor.authorFRANÇOIS, Urielle
dc.contributor.authorCASTELLI, Cecilia
dc.contributor.authorLAMPIN SAINT-AMAUX, Aurélie
dc.contributor.authorLEPLEUX, Marilyn
dc.contributor.authorMOLLE, Pablo
dc.contributor.authorVELEZ, Legeolas
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDEJEAN, Cyril
dc.contributor.authorLANORE, Frédéric
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHERRY, Cyril
dc.contributor.authorCHOQUET, Daniel
dc.contributor.authorHUMEAU, Yann
dc.date.accessioned2023-05-04T14:14:57Z
dc.date.available2023-05-04T14:14:57Z
dc.date.created2023
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173254
dc.description.abstractEnConsolidation of recent memory depends on hippocampal activities during resting periods that immediately follows the memory encoding. There, Slow Save Sleep phases appear as privileged periods for memory consolidation as hosting the ripple activities, which are fast oscillations generated within the hippocampus whose inactivation leads to memory impairment. If a strong correlation exists between these replays of recent experience and the persistence of behavioural adaptations, the mobilisation, the localization and the importance of synaptic plasticity events in this process is largely unknown. To question this issue, we used cell-surface AMPAR immobilisation to block post-synaptic LTP within the hippocampal region at various steps of the memory process. 1- Our results show that hippocampal synaptic plasticity is engaged during the consolidation but is dispensable during the encoding or recall of a working memory based spatial memory task. 2- Blockade of plasticity during sleep leads to apparent forgetting of the encoded rule. 3- In vivo recordings of ripple activities during resting periods show a strong impact of AMPAR immobilization solely, prominent when a rule has been recently encoded. 4- In situ examination of the interplay between AMPAR mobility, hippocampal plasticity and spontaneous ripple activities pointed that post-synaptic plasticity at CA3-CA3 recurrent synapses support ripple generation. As crucial results were reproduced using another AMPARM blockade strategy, we propose that after rule encoding, post-synaptic AMPAR mobility at CA3 recurrent synapses support the generation of ripples necessary for rule consolidation.
dc.language.isoENen_US
dc.title.enCA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1101/2023.03.28.534509en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamCircuits neuronaux des apprentissages associatifsen_US
bordeaux.import.sourcehal
hal.identifierhal-04049962
hal.version1
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=EL-OUSSINI,%20Hajer&ZHANG,%20Chun-Lei&FRAN%C3%87OIS,%20Urielle&CASTELLI,%20Cecilia&LAMPIN%20SAINT-AMAUX,%20Aur%C3%A9lie&rft.genre=preprint


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