Mostrar el registro sencillo del ítem

dc.rights.licenseopenen_US
dc.contributor.authorLEBRUN-FRENAY, Christine
dc.contributor.authorOKUDA, Darin T
dc.contributor.authorSIVA, Aksel
dc.contributor.authorLANDES-CHATEAU, Cassandre
dc.contributor.authorAZEVEDO, Christina J
dc.contributor.authorMONDOT, Lydiane
dc.contributor.authorCARRA-DALLIÈRE, Clarisse
dc.contributor.authorZEPHIR, Helene
dc.contributor.authorLOUAPRE, Celine
dc.contributor.authorDURAND-DUBIEF, Françoise
dc.contributor.authorLE PAGE, Emmanuelle
dc.contributor.authorBENSA, Caroline
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.contributor.authorCIRON, Jonathan
dc.contributor.authorLAPLAUD, David A
dc.contributor.authorCASEZ, Olivier
dc.contributor.authorMATHEY, Guillaume
dc.contributor.authorDE SEZE, Jerome
dc.contributor.authorZEYDAN, Burcu
dc.contributor.authorMAKHANI, Naila
dc.contributor.authorTUTUNCU, Melih
dc.contributor.authorLEVRAUT, Michael
dc.contributor.authorCOHEN, Mikael
dc.contributor.authorTHOUVENOT, Eric
dc.contributor.authorPELLETIER, Daniel
dc.contributor.authorKANTARCI, Orhun H
dc.date.accessioned2023-05-04T13:21:17Z
dc.date.available2023-05-04T13:21:17Z
dc.date.issued2023-03-02
dc.identifier.issn1460-2156en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173253
dc.description.abstractEnThe radiologically isolated syndrome (RIS) was defined in 2009 as the presence of asymptomatic, incidentally identified demyelinating-appearing white matter lesions in the central nervous system within individuals lacking symptoms typical of multiple sclerosis. The RIS criteria have been validated and predict the transition to symptomatic MS reliably. The performance of RIS criteria that require fewer MRI lesions is unknown. 2009-RIS subjects, by definition, fulfill 3-4 of 4 criteria for 2005 dissemination in space [DIS] and subjects fulfilling only 1 or 2 lesions in at least one 2017 DIS location were identified within 37 prospective databases. Univariate and multivariate Cox regression models were used to identify predictors of a first clinical event. Performances of different groups were calculated. 747 subjects (72.2% female, mean age 37.7 ± 12.3 years at the index MRI) were included. The mean clinical follow-up time was 46.8 ± 45.4 months. All subjects had focal T2 hyperintensities suggestive of inflammatory demyelination on MRI; 251 (33.6%) fulfilled 1 or 2 2017 DIS criteria (designated as Group 1 and Group 2, respectively), and 496 (66.4%) fulfilled 3 or 4 2005 DIS criteria representing 2009-RIS subjects. Group 1 and 2 subjects were younger than the 2009-RIS Group and were more likely to develop new T2 lesions over time (p < 0.001). Groups 1 and 2 were similar regarding survival distribution and risk factors for transition to multiple sclerosis. At five years, the cumulative probability for a clinical event was 29.0% for Groups 1-2 compared to 38.7% for 2009-RIS (p = 0.0241). The presence of spinal cord lesions on the index scan and CSF-restricted oligoclonal bands in Groups 1-2 increased the risk of symptomatic MS evolution at five years to 38%, comparable to the risk of development in the 2009-RIS group. The presence of new T2 or gadolinium-enhancing lesions on follow-up scans independently increased the risk of presenting with a clinical event (p < 0.001). The 2009-RIS subjects or Group 1-2 with at least 2 of the risk factors for a clinical event demonstrated better sensitivity (86.0%), negative predictive value (73.1%), accuracy (59.8%) and area under the curve (60.7%) compared to other criteria studied. This large prospective cohort brings Class I evidence that subjects with fewer lesions than required in the 2009 RIS criteria evolve directly to a first clinical event at a similar rate when additional risk factors are present. Our results provide a rationale for revisions to existing RIS diagnostic criteria.
dc.language.isoENen_US
dc.subject.enMRI
dc.subject.enDiagnostic criteria
dc.subject.enMultiple sclerosis
dc.subject.enPrognosis
dc.subject.enRadiologically isolated syndrome
dc.title.enThe radiologically isolated syndrome: revised diagnostic criteria
dc.title.alternativeBrainen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/brain/awad073en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36864688en_US
bordeaux.journalBrain - A Journal of Neurologyen_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Brain%20-%20A%20Journal%20of%20Neurology&amp;rft.date=2023-03-02&amp;rft.eissn=1460-2156&amp;rft.issn=1460-2156&amp;rft.au=LEBRUN-FRENAY,%20Christine&amp;OKUDA,%20Darin%20T&amp;SIVA,%20Aksel&amp;LANDES-CHATEAU,%20Cassandre&amp;AZEVEDO,%20Christina%20J&amp;rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem