Mostrar el registro sencillo del ítem

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLAMBERT, Francois
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOMBES, Denis
ORCID: 0000-0003-3732-7261
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSIMMERS, John
ORCID: 0000-0002-7487-4638
IDREF: 244015430
dc.contributor.authorSTRAKA, Hans
dc.date.accessioned2023-05-03T08:48:26Z
dc.date.available2023-05-03T08:48:26Z
dc.date.issued2012-09-25
dc.identifier.issn1879-0445en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173246
dc.description.abstractEnSelf-generated body movements require compensatory eye and head adjustments in order to avoid perturbation of visual information processing. Retinal image stabilization is traditionally ascribed to the transformation of visuovestibular signals into appropriate extraocular motor commands for compensatory ocular movements. During locomotion, however, intrinsic "efference copies" of the motor commands deriving from spinal central pattern generator (CPG) activity potentially offer a reliable and rapid mechanism for image stabilization, in addition to the slower contribution of movement-encoding sensory inputs. Using a variety of in vitro and in vivo preparations of Xenopus tadpoles, we demonstrate that spinal locomotor CPG-derived efference copies do indeed produce effective conjugate eye movements that counteract oppositely directed horizontal head displacements during undulatory tail-based locomotion. The efference copy transmission, by which the extraocular motor system becomes functionally appropriated to the spinal cord, is mediated by direct ascending pathways. Although the impact of the CPG feedforward commands matches the spatiotemporal specificity of classical vestibulo-ocular responses, the two fundamentally different signals do not contribute collectively to image stabilization during swimming. Instead, when the CPG is active, horizontal vestibulo-ocular reflexes resulting from head movements are selectively suppressed. These results therefore challenge our traditional understanding of how animals offset the disruptive effects of propulsive body movements on visual processing. Specifically, our finding that predictive efference copies of intrinsic, rhythmic neural signals produced by the locomotory CPG supersede, rather than supplement, reactive vestibulo-ocular reflexes in order to drive image-stabilizing eye adjustments during larval frog swimming, represents a hitherto unreported mechanism for vertebrate ocular motor control.
dc.description.sponsorshipQuand la moelle épinière parle aux yeux – bases neuronales et plasticité développementale d'un nouveau mécanisme d'ajustement du regard pendant la locomotion des vertébrés - ANR-08-BLAN-0145en_US
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enEye Movements
dc.subject.enFeedback
dc.subject.enSensory
dc.subject.enFixation
dc.subject.enOcular
dc.subject.enHead Movements
dc.subject.enReflex
dc.subject.enVestibulo-Ocular
dc.subject.enSaccades
dc.subject.enSignal Transduction
dc.subject.enSwimming
dc.subject.enXenopus laevis
dc.title.enGaze stabilization by efference copy signaling without sensory feedback during vertebrate locomotion.
dc.title.alternativeCurr Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cub.2012.07.019en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed22840517en_US
bordeaux.journalCurrent Biology - CBen_US
bordeaux.page1649-1658en_US
bordeaux.volume22en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue18en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamMotoPSYNen_US
bordeaux.teamDN3en_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Biology%20-%20CB&rft.date=2012-09-25&rft.volume=22&rft.issue=18&rft.spage=1649-1658&rft.epage=1649-1658&rft.eissn=1879-0445&rft.issn=1879-0445&rft.au=LAMBERT,%20Francois&COMBES,%20Denis&SIMMERS,%20John&STRAKA,%20Hans&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem