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dc.rights.licenseopenen_US
dc.contributor.authorCURRIE, Stephen P.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOMBES, Denis
ORCID: 0000-0003-3732-7261
dc.contributor.authorSCOTT, Nicholas W.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSIMMERS, John
ORCID: 0000-0002-7487-4638
IDREF: 244015430
dc.contributor.authorSILLAR, Keith T.
dc.date.accessioned2023-05-03T08:15:00Z
dc.date.available2023-05-03T08:15:00Z
dc.date.issued2016-03-01
dc.identifier.issn1522-1598en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173243
dc.description.abstractEnLocomotor control requires functional flexibility to support an animal's full behavioral repertoire. This flexibility is partly endowed by neuromodulators, allowing neural networks to generate a range of motor output configurations. In hatchling Xenopus tadpoles, before the onset of free-swimming behavior, the gaseous modulator nitric oxide (NO) inhibits locomotor output, shortening swim episodes and decreasing swim cycle frequency. While populations of nitrergic neurons are already present in the tadpole's brain stem at hatching, neurons positive for the NO-synthetic enzyme, NO synthase, subsequently appear in the spinal cord, suggesting additional as yet unidentified roles for NO during larval development. Here, we first describe the expression of locomotor behavior during the animal's change from an early sessile to a later free-swimming lifestyle and then compare the effects of NO throughout tadpole development. We identify a discrete switch in nitrergic modulation from net inhibition to overall excitation, coincident with the transition to free-swimming locomotion. Additionally, we show in isolated brain stem-spinal cord preparations of older larvae that NO's excitatory effects are manifested as an increase in the probability of spontaneous swim episode occurrence, as found previously for the neurotransmitter dopamine, but that these effects are mediated within the brain stem. Moreover, while the effects of NO and dopamine are similar, the two modulators act in parallel rather than NO operating serially by modulating dopaminergic signaling. Finally, NO's activation of neurons in the brain stem also leads to the release of NO in the spinal cord that subsequently contributes to NO's facilitation of swimming.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAnimals
dc.subject.enBrain Stem
dc.subject.enDopamine
dc.subject.enLarva
dc.subject.enNeural Inhibition
dc.subject.enNitric Oxide
dc.subject.enPeriodicity
dc.subject.enSpinal Cord
dc.subject.enSwimming
dc.subject.enXenopus
dc.title.enA behaviorally related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles.
dc.title.alternativeJ Neurophysiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1152/jn.00283.2015en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed26763775en_US
bordeaux.journalJournal of Neurophysiologyen_US
bordeaux.page1446-1457en_US
bordeaux.volume115en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamMotoPSYNen_US
bordeaux.teamDN3en_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04087312
hal.version1
hal.date.transferred2023-05-03T08:15:03Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Neurophysiology&rft.date=2016-03-01&rft.volume=115&rft.issue=3&rft.spage=1446-1457&rft.epage=1446-1457&rft.eissn=1522-1598&rft.issn=1522-1598&rft.au=CURRIE,%20Stephen%20P.&COMBES,%20Denis&SCOTT,%20Nicholas%20W.&SIMMERS,%20John&SILLAR,%20Keith%20T.&rft.genre=article


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