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dc.rights.licenseopenen_US
dc.contributor.authorFRANCA DE BARROS, Filipa
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBACQUE CAZENAVE, Julien
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorTAILLEBUIS, Coralie
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOURTAND, Gilles
dc.contributor.authorMANUEL, Marin
dc.contributor.authorBRAS, Helene
dc.contributor.authorTAGLIABUE, Michele
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorCOMBES, Denis
ORCID: 0000-0003-3732-7261
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLAMBERT, Francois
dc.contributor.authorBERANECK, Mathieu
dc.date.accessioned2023-05-03T07:28:11Z
dc.date.available2023-05-03T07:28:11Z
dc.date.issued2022-01-24
dc.identifier.issn1879-0445en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173239
dc.description.abstractEnEfference copies are neural replicas of motor outputs used to anticipate the sensory consequences of a self-generated motor action or to coordinate neural networks involved in distinct motor behaviors. An established example of this motor-to-motor coupling is the efference copy of the propulsive motor command, which supplements classical visuo-vestibular reflexes to ensure gaze stabilization during amphibian larval locomotion. Such feedforward replica of spinal pattern-generating circuits produces a spino-extraocular motor coupled activity that evokes eye movements, spatiotemporally coordinated to tail undulation independently of any sensory signal. Exploiting the developmental stages of the frog, studies in metamorphing Xenopus demonstrated the persistence of this spino-extraocular motor command in adults and its developmental adaptation to tetrapodal locomotion. Here, we demonstrate for the first time the existence of a comparable locomotor-to-ocular motor coupling in the mouse. In neonates, ex vivo nerve recordings of brainstem-spinal cord preparations reveal a spino-extraocular motor coupled activity similar to the one described in Xenopus. In adult mice, trans-synaptic rabies virus injections in lateral rectus eye muscle label cervical spinal cord neurons closely connected to abducens motor neurons. Finally, treadmill-elicited locomotion in decerebrated preparations evokes rhythmic eye movements in synchrony with the limb gait pattern. Overall, our data are evidence for the conservation of locomotor-induced eye movements in vertebrate lineages. Thus, in mammals as in amphibians, CPG-efference copy feedforward signals might interact with sensory feedback to ensure efficient gaze control during locomotion.
dc.description.sponsorshipCorrélats neurophysiologiques de l'évolution et du développement des stratégies de stabilisation du regard pendant la locomotion chez les vertébrés - ANR-15-CE32-0007en_US
dc.description.sponsorshipUniversité de Paris - ANR-18-IDEX-0001en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAnimals
dc.subject.enEye Movements
dc.subject.enLocomotion
dc.subject.enMammals
dc.subject.enMice
dc.subject.enMotor Neurons
dc.subject.enReflex
dc.subject.enVestibulo-Ocular
dc.subject.enSpinal Cord
dc.subject.enXenopus laevis
dc.title.enConservation of locomotion-induced oculomotor activity through evolution in mammals.
dc.title.alternativeCurr Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cub.2021.11.022en_US
dc.identifier.pubmed34856124en_US
bordeaux.journalCurrent Biology - CBen_US
bordeaux.page453-461.e4en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamMotoPSYNen_US
bordeaux.teamDN3en_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Biology%20-%20CB&rft.date=2022-01-24&rft.volume=32&rft.issue=2&rft.spage=453-461.e4&rft.epage=453-461.e4&rft.eissn=1879-0445&rft.issn=1879-0445&rft.au=FRANCA%20DE%20BARROS,%20Filipa&BACQUE%20CAZENAVE,%20Julien&TAILLEBUIS,%20Coralie&COURTAND,%20Gilles&MANUEL,%20Marin&rft.genre=article


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