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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorBEYELER, Anna
ORCID: 0000-0003-2371-5706
IDREF: 141902892
dc.contributor.authorRAO, Guillaume
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLADEPECHE, Laurent
dc.contributor.authorJACQUES, Andre
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSIMMERS, John
ORCID: 0000-0002-7487-4638
IDREF: 244015430
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorLE RAY, Didier
ORCID: 0000-0003-2089-9861
IDREF: 141904275
dc.date.accessioned2023-05-02T10:02:16Z
dc.date.available2023-05-02T10:02:16Z
dc.date.issued2013-08-12
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/23951071
dc.identifier.urihttps://hal.archives-ouvertes.fr/hal-01442058
dc.identifier.urioadoi:https://hal.archives-ouvertes.fr/hal-01439760/document
dc.identifier.urioadoi:https://hal.archives-ouvertes.fr/hal-01439760/file/Beyeler%20-%20Plos%20One.pdf
dc.identifier.urioadoi:http://europepmc.org/articles/pmc3741378?pdf=render
dc.identifier.uriftpubmed:oai:pubmedcentral.nih.gov:3741378
dc.identifier.urioai:researchgate.net:255959473
dc.identifier.urioai:crossref.org:10.1371/journal.pone.0071013
dc.identifier.uriftccsdartic:oai:HAL:hal-01442058v1
dc.identifier.urioadoi:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741378
dc.identifier.urioadoi:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741378/pdf
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173231
dc.description.abstractEnDuring frog metamorphosis, the vestibular sensory system remains unchanged, while spinal motor networks undergo a massive restructuring associated with the transition from the larval to adult biomechanical system. We investigated in Xenopus laevis the impact of a pre- (tadpole stage) or post-metamorphosis (juvenile stage) unilateral labyrinthectomy (UL) on young adult swimming performance and underlying spinal locomotor circuitry. The acute disruptive effects on locomotion were similar in both tadpoles and juvenile frogs. However, animals that had metamorphosed with a preceding UL expressed restored swimming behavior at the juvenile stage, whereas animals lesioned after metamorphosis never recovered. Whilst kinematic and electrophysiological analyses of the propulsive system showed no significant differences in either juvenile group, a 3D biomechanical simulation suggested that an asymmetry in the dynamic control of posture during swimming could account for the behavioral restoration observed in animals that had been labyrinthectomized before metamorphosis. This hypothesis was subsequently supported by in vivo electromyography during free swimming and in vitro recordings from isolated brainstem/spinal cord preparations. Specifically, animals lesioned prior to metamorphosis at the larval stage exhibited an asymmetrical propulsion/posture coupling as a post-metamorphic young adult. This developmental alteration was accompanied by an ipsilesional decrease in propriospinal coordination that is normally established in strict left-right symmetry during metamorphosis in order to synchronize dorsal trunk muscle contractions with bilateral hindlimb extensions in the swimming adult. Our data thus suggest that a disequilibrium in descending vestibulospinal information during Xenopus metamorphosis leads to an altered assembly of adult spinal locomotor circuitry. This in turn enables an adaptive compensation for the dynamic postural asymmetry induced by the vestibular imbalance and the restoration of functionally-effective behavior.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourceoadoi_repo
dc.sourcebase
dc.sourceresearchgate
dc.sourcecrossref
dc.title.enVestibular Lesion-Induced Developmental Plasticity in Spinal Locomotor Networks during Xenopus laevis Metamorphosis
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0071013en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]
dc.identifier.pubmed23951071en_US
bordeaux.journalPLoS ONEen_US
bordeaux.pagee71013en_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamDN3en_US
bordeaux.teamMotoPSYNen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS%20ONE&rft.date=2013-08-12&rft.volume=8&rft.issue=8&rft.spage=e71013&rft.epage=e71013&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=BEYELER,%20Anna&RAO,%20Guillaume&LADEPECHE,%20Laurent&JACQUES,%20Andre&SIMMERS,%20John&rft.genre=article


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