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dc.rights.licenseopenen_US
dc.contributor.authorDIAZ, Laurine
dc.contributor.authorEIDEN, Celine
dc.contributor.authorJOUANJUS, Emilie
dc.contributor.authorFRAUGER, Elisabeth
dc.contributor.authorFOUILHE, Nathalie
dc.contributor.authorDJEZZAR, Samira
dc.contributor.authorGIBAJA, Valerie
dc.contributor.authorBOUCHER, Alexandra
dc.contributor.authorLE BOISSELIER, Reynald
dc.contributor.authorLIBERT, Frederic
dc.contributor.authorCAOUS, Anne-Sylvie
dc.contributor.authorMONZON, Emilie
dc.contributor.authorGUERLAIS, Marylene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDAVELUY, Amelie
dc.contributor.authorFAUCONNEAU, Bernard
dc.contributor.authorPEYRIERE, Helene
dc.date.accessioned2023-04-17T13:06:52Z
dc.date.available2023-04-17T13:06:52Z
dc.date.issued2023-02-15
dc.identifier.issn1958-5578 (Electronic) 0040-5957 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/173024
dc.description.abstractEnOBJECTIVES: Alprazolam, a high-potency and short-acting anxiolytic benzodiazepine, is one of the most misused benzodiazepines in France. In the context of various reports on alprazolam misuse during the COVID-19 pandemic, the objective of this study was to assess alprazolam abuse potential by analyzing French addictovigilance and international data. METHODS: Data collected from 2011 to 2020 using the following epidemiological tools of the French Addictovigilance Network were analyzed: spontaneous reports (SRs), OPPIDUM (addiction care center data), OSIAP (falsified prescriptions), DRAMES (substance-related deaths), and chemical submission surveys. Moreover, the VigiBase™ database was analyzed to evaluate alprazolam abuse liability worldwide. RESULTS: During the study period, 675 SRs concerning alprazolam misuse were recorded (sex ratio: ̴1; median age: 39 years). The desired effects were intensification of the therapeutic anxiolytic effect, euphoric effect, and management of substance withdrawal. Alprazolam was the third and first benzodiazepine listed in OPPIDUM and OSIAP surveys. Analysis of the SR and OPPIDUM data showed a recent increase in the alprazolam-opioid combination. In DRAMES data, alprazolam was directly linked to 11 deaths (associated with opioids in 10/11). VigiBase™ data analysis highlighted that France was the third country with the most cases of alprazolam misuse. The disproportionality analysis showed that in France, alprazolam was associated with higher risk of misuse and dependence compared with other benzodiazepines: reporting odds ratio=1.43, (95% CI: 1.04-1.95) and=1.97 (95% CI:1.50-2.59), respectively. CONCLUSIONS: This study highlighted an increase in various signals of alprazolam abuse in France, and an increased use of the alprazolam-opioid combination that was also linked to most of the recorded alprazolam-linked deaths. These signals have been reported also in the international literature, and should be thoroughly investigated.
dc.language.isoENen_US
dc.subject.enAlprazolam
dc.subject.enAddictovigilance
dc.subject.enMisuse
dc.subject.enVigiBase™
dc.title.enAlprazolam misuse: Analysis of French Addictovigilance Network data from 2011 to 2020
dc.title.alternativeTherapieen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.therap.2023.02.002en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36918317en_US
bordeaux.journalTherapiesen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Therapies&rft.date=2023-02-15&rft.eissn=1958-5578%20(Electronic)%200040-5957%20(Linking)&rft.issn=1958-5578%20(Electronic)%200040-5957%20(Linking)&rft.au=DIAZ,%20Laurine&EIDEN,%20Celine&JOUANJUS,%20Emilie&FRAUGER,%20Elisabeth&FOUILHE,%20Nathalie&rft.genre=article


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