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dc.rights.licenseopenen_US
dc.contributor.authorVANHERSECKE, Lucile
dc.contributor.authorBOUGOUIN, Antoine
dc.contributor.authorCROMBE, Amandine
dc.contributor.authorBRUNET, Maxime
dc.contributor.authorSOFEU, Casimir
dc.contributor.authorPARRENS, Marie
dc.contributor.authorPIERRON, Hugo
dc.contributor.authorBONHOMME, Benjamin
dc.contributor.authorLEMBEGE, Nicolas
dc.contributor.authorREY, Christophe
dc.contributor.authorVELASCO, Valerie
dc.contributor.authorSOUBEYRAN, Isabelle
dc.contributor.authorBEGUERET, Hugues
dc.contributor.authorBESSEDE, Alban
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELLERA, Carine
dc.contributor.authorSCOAZEC, Jean-Yves
dc.contributor.authorITALIANO, Antoine
dc.contributor.authorSAUTES-FRIDMAN, Catherine
dc.contributor.authorFRIDMAN, Wolf H.
dc.contributor.authorLE LOARER, Francois
dc.date.accessioned2023-03-20T10:32:17Z
dc.date.available2023-03-20T10:32:17Z
dc.date.issued2023-01-18
dc.identifier.issn1530-0307 (Electronic) 0023-6837 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172380
dc.description.abstractEnMature tertiary lymphoid structures (mTLSs) are organized lymphoid structures containing B lymphocytes admixed to CD23+ follicular dendritic cells. Their presence has been linked to improved survival and sensitivity to immune checkpoint inhibitors in several cancers, emerging as a promising pancancer biomarker. However, the requirements for any biomarker are clear methodology, proven feasibility, and reliability. In 357 patients' samples, we studied tertiary lymphoid structures (TLSs) parameters using multiplex immunofluorescence (mIF), hematoxylin-eosin-saffron (HES) staining, double CD20/CD23 staining, and single CD23 immunohistochemistry. The cohort included carcinomas (n = 211) and sarcomas (n = 146), gathering biopsies (n = 170), and surgical specimens (n = 187). mTLSs were defined as TLSs containing either a visible germinal center on HES staining or CD23+ follicular dendritic cells. Focusing on 40 TLSs assessed using mIF, double CD20/CD23 staining was less sensitive than mIF to assess maturity in 27.5% (n = 11/40) but was rescued by single CD23 staining in 90.9% (n = 10/11). In 97 patients, several samples (n = 240) were reviewed to characterize TLS distribution. The likelihood of finding TLSs in surgical material was 6.1 higher than in biopsy and 2.0 higher in primary samples than in metastasis after adjustment with a type of sample. Interrater agreement rates over 4 examiners were 0.65 (Fleiss kappa, 95% CI [0.46; 0.90]) for the presence of TLS and 0.90 for maturity (95% CI [0.83;0.99]). In this study, we propose a standardized method to screen mTLSs in cancer samples using HES staining and immunohistochemistry that can be applied to all specimens.
dc.language.isoENen_US
dc.subject.enImmune checkpoint inhibitors
dc.subject.enImmunotherapy
dc.subject.enTertiary lymphoid structures (TLS)
dc.subject.enTumor microenvironment
dc.title.enStandardized Pathology Screening of Mature Tertiary Lymphoid Structures in Cancers
dc.title.alternativeLab Investen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.labinv.2023.100063en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36801637en_US
bordeaux.journalLaboratory Investigationen_US
bordeaux.volume103en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04037238
hal.version1
hal.date.transferred2023-03-20T10:32:21Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Laboratory%20Investigation&rft.date=2023-01-18&rft.volume=103&rft.issue=5&rft.eissn=1530-0307%20(Electronic)%200023-6837%20(Linking)&rft.issn=1530-0307%20(Electronic)%200023-6837%20(Linking)&rft.au=VANHERSECKE,%20Lucile&BOUGOUIN,%20Antoine&CROMBE,%20Amandine&BRUNET,%20Maxime&SOFEU,%20Casimir&rft.genre=article


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