Mostrar el registro sencillo del ítem

The respiratory microbiota alpha-diversity in chronic lung diseases: a systematic review and meta-analysis

dc.rights.licenseopenen_US
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAVALOS FERNANDEZ, Marta
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorALIN, Thibaud
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMETAYER, Clemence
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorENAUD, Raphael
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDELHAES, Laurence
dc.date.accessioned2023-03-07T08:23:39Z
dc.date.available2023-03-07T08:23:39Z
dc.date.issued2022
dc.date.conference2022-04
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172191
dc.description.abstractEnImbalance in microbial composition (i.e. dysbiosis) in the gut microbiome is consensually considered an indicator of deteriorated health and has been associated to different chronic health conditions. However, there is no clear evidence how this generalizes to the other human microbiomes. Especially, researches on the relationship between respiratory microbiota imbalance and chronic lung diseases are recent whereas microbial colonization of the airways respiratory tract have characterized chronic lung diseases. Imbalance is mainly measured through the relative abundance of microbial species in space and time within a given community (i.e. alpha-diversity). Identifying a range of values in alpha-diversity when comparing exacerbated, stable patients and healthy subjects may lead to identify new biomarker in chronic respiratory diseases. In the present work, we propose a systematic review of studies investigating the lung microbiota alpha-diversity in patients with chronic respiratory diseases in which a control group based on disease status or healthy subjects is provided for comparison. We focused on the most common measures of alpha-diversity (Chao1, Shannon, and Simpson) indexes and the most common chronic diseases (asthma, chronic obstructive pulmonary disease –COPD-, cystic fibrosis –CF-, bronchiectasis, and pulmonary hypertension). Subsequently, we conducted a meta-analysis based on random-effects models using the R package metafor to characterize the difference in alpha-diversity indexes when comparing cases to controls. We also explored heterogeneity of sources and risk of bias though Factor Analysis of Mixed Data (FAMD) using the FactoMineR R package. After removing duplicate records, we screened 351 articles on title and abstract, of which 27 met our inclusion criteria for the systematic review. Finally, data from 25 studies were used in the meta-analysis. Eight studies deal with CF, 8 with COPD, 10 with asthma and 1 with bronchiectasis. All of the studies dedicated to the respiratory tract microbiota, mainly based on sputum samples analysis and, the majority of the studies used metataxonomy approaches. As highlighted by the meta-analysis, these metataxonomy methods exhibited numerous heterogeneities. Differences in alpha-diversity indexes between healthy and diseased people were observed only in some of the diseases studied. However, prudence is required in its interpretation because of substantial heterogeneity.
dc.language.isoENen_US
dc.title.enThe respiratory microbiota alpha-diversity in chronic lung diseases: a systematic review and meta-analysis
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.title32nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)en_US
bordeaux.countrypten_US
bordeaux.teamSISTM_BPHen_US
bordeaux.conference.cityLisbonneen_US
bordeaux.peerReviewedouien_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2022&rft.au=AVALOS%20FERNANDEZ,%20Marta&ALIN,%20Thibaud&METAYER,%20Clemence&THIEBAUT,%20Rodolphe&ENAUD,%20Raphael&rft.genre=conference


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem