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Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

dc.rights.licenseopenen_US
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorALEXANDRE, Marie
dc.contributor.authorMARLIN, Romain
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPRAGUE, Melanie
dc.contributor.authorCOLEON, Severin
dc.contributor.authorKAHLAOUI, Nidhal
dc.contributor.authorCARDINAUD, Sylvain
dc.contributor.authorNANINCK, Thibaut
dc.contributor.authorDELACHE, Benoit
dc.contributor.authorSURENAUD, Mathieu
dc.contributor.authorGALHAUT, Mathilde
dc.contributor.authorDEREUDDRE-BOSQUET, Nathalie
dc.contributor.authorCAVARELLI, Mariangela
dc.contributor.authorMAISONNASSE, Pauline
dc.contributor.authorCENTLIVRE, Mireille
dc.contributor.authorLACABARATZ, Christine
dc.contributor.authorWIEDEMANN, Aurelie
dc.contributor.authorZURAWSKI, Sandra
dc.contributor.authorZURAWSKI, Gerard
dc.contributor.authorSCHWARTZ, Olivier
dc.contributor.authorSANDERS, Rogier W
dc.contributor.authorLE GRAND, Roger
dc.contributor.authorLEVY, Yves
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.date.accessioned2023-03-06T11:11:24Z
dc.date.available2023-03-06T11:11:24Z
dc.date.issued2022-07-08
dc.identifier.issn2050-084Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172172
dc.description.abstractEnThe definition of correlates of protection is critical for the development of next-generation SARS-CoV-2 vaccine platforms. Here, we propose a model-based approach for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics and data mining of immunological markers. The application to three different studies in non-human primates evaluating SARS-CoV-2 vaccines based on CD40-targeting, two-component spike nanoparticle and mRNA 1273 identifies and quantifies two main mechanisms that are a decrease of rate of cell infection and an increase in clearance of infected cells. Inhibition of RBD binding to ACE2 appears to be a robust mechanistic correlate of protection across the three vaccine platforms although not capturing the whole biological vaccine effect. The model shows that RBD/ACE2 binding inhibition represents a strong mechanism of protection which required significant reduction in blocking potency to effectively compromise the control of viral replication.
dc.description.sponsorshipInitiative for the creation of a Vaccine Research Institute - ANR-10-LABX-0077en_US
dc.description.sponsorshipInfrastructure nationale pour la modélisation des maladies infectieuses humainesen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectGraw
dc.subjectFrederik
dc.subjectDavenport
dc.subjectMiles P
dc.subject.encorrelate of protection
dc.subject.enneutralization
dc.subject.enSARS-CoV-2
dc.subject.envaccines
dc.title.enModelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection
dc.typeArticle de revueen_US
dc.identifier.doi10.7554/eLife.75427en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35801637en_US
bordeaux.journaleLifeen_US
bordeaux.pagee75427en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eLife&rft.date=2022-07-08&rft.volume=11&rft.spage=e75427&rft.epage=e75427&rft.eissn=2050-084X&rft.issn=2050-084X&rft.au=ALEXANDRE,%20Marie&MARLIN,%20Romain&PRAGUE,%20Melanie&COLEON,%20Severin&KAHLAOUI,%20Nidhal&rft.genre=article


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