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Association of lipid-lowering drugs, anti-diabetic drugs, non-steroidal anti-inflammatory drugs, and levodopa with age-related macular degeneration in Europeans: A meta-analysis of the European Eye Epidemiology (E3) - consortium

dc.rights.licenseopenen_US
dc.contributor.authorMAUSCHITZ, Matthias M.
dc.contributor.authorSCHUSTER, Alexander Karl-Georg
dc.contributor.authorKHAWAJA, Anthony P.
dc.contributor.authorBIKBOV, Mukharram
dc.contributor.authorHOGG, Ruth E.
dc.contributor.authorRAUSCHER, Franziska G.
dc.contributor.authorERKE, Maja Gran
dc.contributor.authorTOPOUZIS, Fotis
dc.contributor.authorBRANDL, Caroline
dc.contributor.authorCREUZOT‐GARCHER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cécile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
dc.contributor.authorHENSE, Hans-Werner
dc.contributor.authorSILVA, Rufino
dc.contributor.authorPIERMAROCCHI, Stefano
dc.contributor.authorRITCHIE, Karen
dc.contributor.authorFINGER, Robert
dc.date.accessioned2023-03-06T09:38:48Z
dc.date.available2023-03-06T09:38:48Z
dc.date.issued2022-05-01
dc.date.conference2022-05-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172164
dc.description.abstractEnPurpose : Changes in lipid metabolism, chronic inflammation and increased oxidative stress have been discussed as patho-etiogenetic drivers in age-related macular degeneration (AMD). Systemic medication, such as lipid-lowering drugs (LLD) and anti-diabetic drugs, affect these pathways and may therefore also play a role in AMD pathogenesis. We aimed to investigate associations of commonly used systemic drugs with AMD prevalence in the European population. Methods : We included 38,694 adults from 14 population-based studies from the European Eye Epidemiology (E3) consortium. We performed multivariable logistic regression modelling to examine medication use association with prevalence of AMD as well as late AMD. Analyses were carried out separately by study and results pooled using random effects meta-analysis. We conducted these analyses separately for LLD, anti-diabetic drugs, non-steroidal anti-inflammatory drugs (NSAID), and L-Dopa. Results : Between studies, mean age ranged from 61.5 ± 7.1 to 82.6 ± 3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and any late AMD, respectively. In the meta-analysis of our multivariable models, LLD and anti-diabetic drugs were associated with lower AMD prevalence (OR 0.85, 95% confidence interval (CI)=0.79 - 0.91 and OR 0.78, 95% CI=0.66 - 0.91). We found no association with late AMD or with any other medication. Conclusions : Our study shows an association of LLD and anti-diabetic drug use with lower AMD prevalence across multiple European cohorts. Our findings support the importance of metabolic processes in the complex etiology of AMD.
dc.language.isoENen_US
dc.title.enAssociation of lipid-lowering drugs, anti-diabetic drugs, non-steroidal anti-inflammatory drugs, and levodopa with age-related macular degeneration in Europeans: A meta-analysis of the European Eye Epidemiology (E3) - consortium
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.page1 p.en_US
bordeaux.volume63en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.titleAnnual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO)en_US
bordeaux.countryusen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.conference.cityDenveren_US
bordeaux.peerReviewedouien_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2022-05-01&rft.volume=63&rft.spage=1%20p.&rft.epage=1%20p.&rft.au=MAUSCHITZ,%20Matthias%20M.&SCHUSTER,%20Alexander%20Karl-Georg&KHAWAJA,%20Anthony%20P.&BIKBOV,%20Mukharram&HOGG,%20Ruth%20E.&rft.genre=conference


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