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Impact of Albumin Assays in the Diagnosis of Malnutrition in Hemodialysis Patients: A Cohort Study.

dc.rights.licenseopenen_US
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorRAMI ARAB, Lila
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorDABERNAT, Sandrine
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorBOUTIN, Julian
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorBORDENAVE, Chloé
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorKARMANI, Malek
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorCOLOMBIÈS, Brigitte
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorDELMAS, Yahsou
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorDE-LA-FAILLE, Renaud
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorDE PRÉCIGOUT, Valérie
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRUBIN, Sébastien
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorMOREAU, Karine
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBATS, Marie-Lise
dc.date.accessioned2023-03-03T10:41:27Z
dc.date.available2023-03-03T10:41:27Z
dc.date.issued2022-10-19
dc.identifier.issn1532-8503en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172153
dc.description.abstractEnIn hemodialysis (HD) patients, malnutrition should be diagnosed by several assessment tools including a plasma albumin concentration of less than 3.8 g/dL or 3.5 g/dL using bromocresol green or immunonephelometry (IN), respectively. However, albumin measurement is not yet standardized and two alternative methods are also commonly used in laboratories: bromocresol purple (BCP) and immunoturbidimetry (IT). This study aimed to revisit the hypoalbuminemia thresholds for BCP and IT, in HD patients. Plasma albumin was measured by the four analytical methods during the monthly HD nutritional assessment of 103 prospectively included patients. Significant differences in albumin levels were observed in HD patients depending on the method used. Using BCP or IT with the cut-off at 3.5 g/dL (determined for the general population) we obtained 33% and 9.7% of false hypoalbuminemia in comparison to IN (mean bias of -0.4 g/dL and -0.065 g/dL, respectively). The best hypoalbuminemia threshold for BCP was 3.05 g/dL and 3.4 g/dL for IT. Twenty percent of HD patients were classified as malnourished when albumin was determined by IN. Similar rates were obtained using the new hypoalbuminemia cut-offs for BCP (18.5%) and IT (19.5%). To avoid nutritional misclassification of HD patients, we should adjust hypoalbuminemia thresholds when BCP or IT methods are used in laboratories.
dc.language.isoENen_US
dc.subject.enAlbumin; analytical method; cut-off; hemodialysis; malnutrition
dc.title.enImpact of Albumin Assays in the Diagnosis of Malnutrition in Hemodialysis Patients: A Cohort Study.
dc.title.alternativeJ Ren Nutren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1053/j.jrn.2022.10.001en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed36270483en_US
bordeaux.journalJournal of Renal Nutritionen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04013128
hal.version1
hal.date.transferred2023-03-03T10:41:34Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Renal%20Nutrition&rft.date=2022-10-19&rft.eissn=1532-8503&rft.issn=1532-8503&rft.au=RAMI%20ARAB,%20Lila&DABERNAT,%20Sandrine&BOUTIN,%20Julian&BORDENAVE,%20Chlo%C3%A9&KARMANI,%20Malek&rft.genre=article


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