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Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study

dc.rights.licenseopenen_US
dc.contributor.authorSCHLEMMER, Frederic
dc.contributor.authorVALENTIN, Simon
dc.contributor.authorBOYER, Laurent
dc.contributor.authorGUILLAUMOT, Anne
dc.contributor.authorCHABOT, Francois
dc.contributor.authorDUPIN, Clairelyne
dc.contributor.authorLE GUEN, Pierre
dc.contributor.authorLORILLON, Gwenael
dc.contributor.authorBERGERON, Anne
dc.contributor.authorBASILLE, Damien
dc.contributor.authorDELOMEZ, Julia
dc.contributor.authorANDREJAK, Claire
dc.contributor.authorBONNEFOY, Valentine
dc.contributor.authorGOUSSAULT, Helene
dc.contributor.authorASSIE, Jean-Baptiste
dc.contributor.authorCHOINIER, Pascaline
dc.contributor.authorRUPPERT, Anne-Marie
dc.contributor.authorCADRANEL, Jacques
dc.contributor.authorMENNITTI, Maria Chiara
dc.contributor.authorROUMILA, Mehdi
dc.contributor.authorCOLIN, Charlotte
dc.contributor.authorGUNTHER, Sven
dc.contributor.authorSANCHEZ, Olivier
dc.contributor.authorGILLE, Thomas
dc.contributor.authorSESE, Lucile
dc.contributor.authorUZUNHAN, Yurdagul
dc.contributor.authorFAURE, Morgane
dc.contributor.authorPATOUT, Maxime
dc.contributor.authorMORELOT-PANZINI, Capucine
dc.contributor.authorLAVENEZIANA, Pierantonio
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorZYSMAN, Maeva
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBLANCHARD, Elodie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorGIRAUD, Violaine
dc.contributor.authorGIROUX-LEPRIEUR, Etienne
dc.contributor.authorHABIB, Stefanie
dc.contributor.authorROCHE, Nicolas
dc.contributor.authorDINH-XUAN, Anh Tuan
dc.contributor.authorSIFAOUI, Islem
dc.contributor.authorBRILLET, Pierre-Yves
dc.contributor.authorJUNG, Camille
dc.contributor.authorBOUTIN, Emmanuelle
dc.contributor.authorLAYESE, Richard
dc.contributor.authorCANOUI-POITRINE, Florence
dc.contributor.authorMAITRE, Bernard
dc.date.accessioned2023-02-23T10:04:35Z
dc.date.available2023-02-23T10:04:35Z
dc.date.issued2023-01-20
dc.identifier.issn1399-3003 (Electronic) 0903-1936 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172074
dc.description.abstractEnBACKGROUND: Survivors of severe-to-critical COVID-19 may have functional impairment, radiological sequelae and persistent symptoms requiring prolonged follow-up. This pragmatic study aimed to describe their clinical follow-up and determine their respiratory recovery trajectories, and factors that could influence them and their health-related quality of life. METHODS: Adults hospitalised for severe-to-critical COVID-19 were evaluated at 3 months and up to 12 months post-hospital discharge in this prospective, multicentre, cohort study. RESULTS: Among 485 enrolled participants, 293 (60%) were reassessed at 6 months and 163 (35%) at 12 months; 89 (51%) and 47 (27%) of the 173 ones initially managed with standard oxygen were reassessed at 6 and 12 months, respectively. At 3 months, 34%, 70% and 56% of the participants had a restrictive lung defect, impaired DL(CO) and significant radiological sequelae, respectively. During extended follow-up, DL(CO) and FVC (% of predicted value) increased by means of +4 points at 6 months, and +6 points at 12 months. Sex, body mass index, chronic respiratory disease, immunosuppression, pneumonia extent or corticosteroid use during acute COVID-19 and prolonged invasive mechanical ventilation (IMV) were associated with DL(CO) at month 3, but not its trajectory thereafter. Among 475 (98%) patients with at least one chest computed-tomography scan during follow-up, 196 (41%) had significant sequelae on their last images. CONCLUSION: Although pulmonary function and radiological abnormalities improved up to 1 year post-acute-COVID-19, high percentages of severe-to-critical disease survivors, including a notable proportion of those managed with standard oxygen, had significant lung sequelae and residual symptoms justifying prolonged follow-up.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.title.enRespiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study
dc.title.alternativeEur Respir Jen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1183/13993003.01532-2022en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36669777en_US
bordeaux.journalEuropean Respiratory Journalen_US
bordeaux.volume61en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Respiratory%20Journal&rft.date=2023-01-20&rft.volume=61&rft.issue=2&rft.eissn=1399-3003%20(Electronic)%200903-1936%20(Linking)&rft.issn=1399-3003%20(Electronic)%200903-1936%20(Linking)&rft.au=SCHLEMMER,%20Frederic&VALENTIN,%20Simon&BOYER,%20Laurent&GUILLAUMOT,%20Anne&CHABOT,%20Francois&rft.genre=article


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