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Albuminuric diabetic kidney disease predicts foot ulcers in type 2 diabetes

dc.rights.licenseopenen_US
dc.contributor.authorBORDERIE, Gauthier
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorFOUSSARD, Ninon
dc.contributor.authorLARROUMET, Alice
dc.contributor.authorBLANCO-BAILLET, Laurence
dc.contributor.authorDOMENGE, Frederic
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorDUCASSE, Eric
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorCARADU, Caroline
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
IDREF: 069788146
dc.date.accessioned2023-02-23T08:10:48Z
dc.date.available2023-02-23T08:10:48Z
dc.date.issued2023-01-07
dc.identifier.issn1873-460X (Electronic) 1056-8727 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/172066
dc.description.abstractEnDiabetic Foot Ulcers (DFU) are feared among individuals with diabetic kidney disease (DKD), but it is unclear whether they are more frequent, especially in normoalbuminuric DKD. Five hundred and twenty patients admitted in our diabetology ward from 2007 to 2017 were followed up during 54 ± 26 months. New DFUs were registered, and their relationship with the initial renal status was analyzed by LogRank and multivariate Cox regression analysis. The 520 subjects were mainly men (57.9 %), 62 ± 9 years old, with a duration of diabetes of 14 ± 10 years, HbA1c: 8.7 ± 1.8 % (72 ± 19 mmol/mol), and complications: 33.7 % macroangiopathies, 22.1 % previous foot ulcers, 44.8 % DKD, 26.9 % retinopathies. Fifty-seven new DFU occurred, mainly in subjects with DKD. DKD was related to later DFU (HR: 1.79; 95%CI: 1.05-3.07), this relationship stayed significant adjusted for age, gender, and a history of previous DFU (HR: 3.61; 95%CI: 2.11-6.18), and further adjusted for the duration of diabetes, HbA1c, BMI, arterial hypertension, and dyslipidemia. Among the 233 subjects with DKD, 129 (55.3 %) had an isolated AER > 30 mg/24H, 41 (17.6 %) had an isolated eGFR<60 mL/min/1.73 m(2), and 63 (27.0 %) cumulated both abnormalities. By Cox regression analysis adjusted for age and gender, albuminuric DKDs were related to later DFU: with eGFR≥60: HR: 1.91; 95%CI: 1.02-3.59, with eGFR<60: HR: 2.53; 95%CI: 1.25-5.10, whereas normoalbuminuric DKD was not: HR: 1.04; 95%CI: 0.35-3.07, despite similar rates of neuropathies, peripheral arterial diseases, and retinopathies. In people with type 2 diabetes, albuminuric DKD was associated with two to three folds increased risk of DFUs, whereas normoalbuminuric DKD was not.
dc.language.isoENen_US
dc.title.enAlbuminuric diabetic kidney disease predicts foot ulcers in type 2 diabetes
dc.title.alternativeJ Diabetes Complicationsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jdiacomp.2023.108403en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36641879en_US
bordeaux.journalJournal of Diabetes and its Complicationsen_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04001613
hal.version1
hal.date.transferred2023-02-23T08:10:53Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Diabetes%20and%20its%20Complications&amp;rft.date=2023-01-07&amp;rft.volume=37&amp;rft.issue=2&amp;rft.eissn=1873-460X%20(Electronic)%201056-8727%20(Linking)&amp;rft.issn=1873-460X%20(Electronic)%201056-8727%20(Linking)&amp;rft.au=BORDERIE,%20Gauthier&amp;FOUSSARD,%20Ninon&amp;LARROUMET,%20Alice&amp;BLANCO-BAILLET,%20Laurence&amp;DOMENGE,%20Frederic&amp;rft.genre=article


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