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dc.rights.licenseopenen_US
dc.contributor.authorLABAT, J.
dc.contributor.authorBROCARD, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELAROUSSI, Yaniss
dc.contributor.authorBAR, C.
dc.contributor.authorGOTCHAC, Julien, J.
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorCHATEIL, Jean-Francois
dc.contributor.authorBRISSAUD, O.
dc.date.accessioned2023-02-16T10:53:39Z
dc.date.available2023-02-16T10:53:39Z
dc.date.issued2022-12-13
dc.identifier.issn0929-693xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171972
dc.description.abstractEnAIM: To investigate the clinical, laboratory, electrophysiological, and imaging features associated with death or neurological impairment at 1 year of age in term neonates with hypoxic-ischemic encephalopathy (HIE) treated by therapeutic hypothermia (TH). METHODS: This was a single-center retrospective and descriptive study conducted over a period of 2 years. We included consecutive term newborns with moderate or severe HIE who were treated by TH initiated within the sixth hour after birth and continued for 72 h,. For all patients, brain magnetic resonance imaging (MRI) was performed before the eighth day and a score was established; furthermore, at least two electroencephalograms were recorded. RESULTS: Among the 33 patients included, 20 neonates had a favorable outcome and 13 had an unfavorable outcome. Early clinical seizures (15% vs. 53.8%, p = 0.047), the persistence of a poor prognosis according to the electroencephalogram pattern after TH (0% vs. 69.2%, p = 0.0001), and an elevated score on the early brain MRI (2 vs. 11, p < 0.001) combined with a high lactate/N-acetyl-aspartate ratio (0.52 vs. 1.33, p = 0.008) on spectroscopy were associated with death and a poor outcome. CONCLUSION: A combination of tools can help the medical team to establish the most reliable prognosis for these full-term neonates, to guide care, and to inform parents most appropriately and sincerely.
dc.language.isoENen_US
dc.title.enHypothermia for neonatal hypoxic-ischemic encephalopathy: Retrospective descriptive study of features associated with poor outcome
dc.title.alternativeArch Pediatren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.arcped.2022.08.022en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36522220en_US
bordeaux.journalArchives de Pédiatrieen_US
bordeaux.page93-99en_US
bordeaux.volume30en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamEPICENEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03992121
hal.version1
hal.date.transferred2023-02-16T10:53:41Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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