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Development of the PREDS score to predict in-hospital mortality of patients with Ebola virus disease under advanced supportive care: Results from the EVISTA cohort in the Democratic Republic of the Congo

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorJASPARD, Marie
dc.contributor.authorMULANGU, Sabue
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJUCHET, Sylvain
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSERRA, Beatrice
dc.contributor.authorDICKO, Ibrahim
dc.contributor.authorLANG, Hans-Joeg
dc.contributor.authorBAKA, Baweye Mayoum
dc.contributor.authorKOMANDA, Gaston Musemakweli
dc.contributor.authorKATSAVARA, Jeremie Muhindo
dc.contributor.authorKABUNI, Patricia
dc.contributor.authorMAMBU, Fabrice Mbika
dc.contributor.authorISNARD, Margaux
dc.contributor.authorVANHECKE, Christophe
dc.contributor.authorLETORD, Alexia
dc.contributor.authorDIEYE, Ibrahima
dc.contributor.authorPATTERSON-LOMBA, Oscar
dc.contributor.authorMBAYA, Olivier Tshiani
dc.contributor.authorISEKUSU, Fiston
dc.contributor.authorMANGALA, Donatien
dc.contributor.authorBIAMPATA, Jean Luc
dc.contributor.authorKITENGE, Richard
dc.contributor.authorKINDA, Moumouni
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorANGLARET, Xavier
dc.contributor.authorMUYEMBE, Jean Jacques
dc.contributor.authorKOJAN, Richard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorEZZEDINE, Khaled
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorMALVY, Denis
dc.date.accessioned2023-02-15T11:32:13Z
dc.date.available2023-02-15T11:32:13Z
dc.date.issued2022-12
dc.identifier.issn2589-5370en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171962
dc.description.abstractEnBACKGROUND: As mortality remains high for patients with Ebola virus disease (EVD) despite new treatment options, the ability to level up the provided supportive care and to predict the risk of death is of major importance. This analysis of the EVISTA cohort aims to describe advanced supportive care provided to EVD patients in the Democratic Republic of the Congo (DRC) and to develop a simple risk score for predicting in-hospital death, called PREDS. METHODS: In this prospective cohort (NCT04815175), patients were recruited during the 10(th) EVD outbreak in the DRC across three Ebola Treatment Centers (ETCs). Demographic, clinical, biological, virological and treatment data were collected. We evaluated factors known to affect the risk of in-hospital death and applied univariate and multivariate Cox proportional-hazards analyses to derive the risk score in a training dataset. We validated the score in an internal-validation dataset, applying C-statistics as a measure of discrimination. FINDINGS: Between August 1(st) 2018 and December 31(th) 2019, 711 patients were enrolled in the study. Regarding supportive care, patients received vasopressive drug (n = 111), blood transfusion (n = 101), oxygen therapy (n = 250) and cardio-pulmonary ultrasound (n = 15). Overall, 323 (45%) patients died before day 28. Six independent prognostic factors were identified (ALT, creatinine, modified NEWS2 score, viral load, age and symptom duration). The final score range from 0 to 13 points, with a good concordance (C = 86.24%) and calibration with the Hosmer-Lemeshow test (p = 0.12). INTERPRETATION: The implementation of advanced supportive care is possible for EVD patients in emergency settings. PREDS is a simple, accurate tool that could help in orienting early advanced care for at-risk patients after external validation. FUNDING: This study was funded by ALIMA.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enEbola virus
dc.subject.enSub-Saharan Africa
dc.subject.enSupportive care
dc.subject.enOutcome
dc.subject.enPredictive score
dc.subject.enIn-hospital mortality
dc.title.enDevelopment of the PREDS score to predict in-hospital mortality of patients with Ebola virus disease under advanced supportive care: Results from the EVISTA cohort in the Democratic Republic of the Congo
dc.title.alternativeEClinicalMedicineen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.eclinm.2022.101699en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36263398en_US
bordeaux.journalEClinicalMedicineen_US
bordeaux.volume54en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03990430
hal.version1
hal.date.transferred2023-02-15T11:32:51Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EClinicalMedicine&rft.date=2022-12&rft.volume=54&rft.eissn=2589-5370&rft.issn=2589-5370&rft.au=JASPARD,%20Marie&MULANGU,%20Sabue&JUCHET,%20Sylvain&SERRA,%20Beatrice&DICKO,%20Ibrahim&rft.genre=article


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