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Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa

dc.rights.licenseopenen_US
dc.contributor.authorEZINMEGNON, Sem
dc.contributor.authorMOMMERT, Marine
dc.contributor.authorBARTOLO, Francois
dc.contributor.authorAGBOTA, Gino
dc.contributor.authorDARIUS, Sossou
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBRIAND, Valerie
dc.contributor.authorD'ALMEIDA, Marceline
dc.contributor.authorALAO, Maroufou Jules
dc.contributor.authorDOSSOU-DAGBA, Ida
dc.contributor.authorMASSOUGBODJI, Achille
dc.contributor.authorLAUSTEN-THOMSEN, Ulrik
dc.contributor.authorPACHOT, Alexandre
dc.contributor.authorVACHOT, Laurence
dc.contributor.authorYUGUEROS-MARCOS, Javier
dc.contributor.authorBRENGEL-PESCE, Karen
dc.contributor.authorFIEVET, Nadine
dc.contributor.authorTISSIERES, Pierre
dc.date.accessioned2023-02-15T10:49:14Z
dc.date.available2023-02-15T10:49:14Z
dc.date.issued2022-12-12
dc.identifier.issn2045-2322en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171959
dc.description.abstractEnFew biomarkers for sepsis diagnosis are commonly used in neonatal sepsis. While the role of host response is increasingly recognized in sepsis pathogenesis and prognosis, there is a need for evaluating new biomarkers targeting host response in regions where sepsis burden is high and medico-economic resources are scarce. The objective of the study is to evaluate diagnostic and prognostic accuracy of biomarkers of neonatal sepsis in Sub Saharan Africa. This prospective multicentre study included newborn infants delivered in the Abomey-Calavi region in South Benin and their follow-up from birth to 3 months of age. Accuracy of transcriptional (CD74, CX3CR1), proteic (PCT, IL-6, IL-10, IP-10) biomarkers and clinical characteristics to diagnose and prognose neonatal sepsis were measured. At delivery, cord blood from all consecutive newborns were sampled and analysed, and infants were followed for a 12 weeks' period. Five hundred and eighty-one newborns were enrolled. One hundred and seventy-two newborns developed neonatal sepsis (29.6%) and death occurred in forty-nine infants (8.4%). Although PCT, IL-6 and IP-10 levels were independently associated with sepsis diagnosis, diagnostic accuracy of clinical variables combinations was similar to combinations with biomarkers and superior to biomarkers alone. Nonetheless, CD74, being the only biomarkers independently associated with mortality, showed elevated prognosis accuracy (AUC > 0.9) either alone or in combination with other biomarkers (eg. CD74/IP-10) or clinical criterion (eg. Apgar 1, birth weight). These results suggest that cord blood PCT had a low accuracy for diagnosing early onset neonatal sepsis in Sub Saharan African neonates, while association of clinical criterion showed to be more accurate than any biomarkers taken independently. At birth, CD74, either associated with IP-10 or clinical criterion, had the best accuracy in prognosing sepsis mortality.Trial registration Clinicaltrial.gov registration number: NCT03780712. Registered 19 December 2018. Retrospectively registered.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enProspective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa
dc.title.alternativeSci Repen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41598-022-25892-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36509812en_US
bordeaux.journalScientific Reportsen_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03990307
hal.version1
hal.date.transferred2023-02-15T10:49:18Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2022-12-12&rft.volume=12&rft.issue=1&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=EZINMEGNON,%20Sem&MOMMERT,%20Marine&BARTOLO,%20Francois&AGBOTA,%20Gino&DARIUS,%20Sossou&rft.genre=article


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