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Maternal occupational exposure to organic solvents and intrauterine growth in the ELFE cohort

dc.rights.licenseopenen_US
dc.contributor.authorENDERLE, Isabelle
dc.contributor.authorDE LAUZUN, Virginie DE
dc.contributor.authorMETTEN, Marie-Astrid
dc.contributor.authorMONPERRUS, Marion
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELVA, Fleur
dc.contributor.authorBLANC-PETITJEAN, Pauline
dc.contributor.authorDANANCHE, Brigitte
dc.contributor.authorPARIS, Christophe
dc.contributor.authorZAROS, Cecile
dc.contributor.authorLE LOUS, Maela
dc.contributor.authorBERANGER, Remi
dc.contributor.authorGARLANTEZEC, Ronan
dc.date.accessioned2023-02-15T10:39:49Z
dc.date.available2023-02-15T10:39:49Z
dc.date.issued2023-05-01
dc.identifier.issn1096-0953 (Electronic) 0013-9351 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171958
dc.description.abstractEnBACKGROUND: In developed countries, about 15% of women are occupationally exposed to solvents. Associations between this maternal occupational exposure and intrauterine fetal growth are inconsistent, but almost no existing study has investigated this relation by solvent family (oxygenated, petroleum, and chlorinated), although they may affect fetal growth differently. OBJECTIVES: To investigate the relations between maternal occupational solvent exposure, by solvent family, and the risk of neonates born small for gestational age (SGA), or with low birthweight, or with small head circumference (HC). METHODS: Among the 18,040 women included in the Elfe birth cohort, we included 13,026 women who worked during pregnancy (72% of the cohort). Information about maternal occupations and industrial activities during pregnancy was collected by questionnaire at the maternity ward, and completed at 2-month when necessary. Using Matgéné job-exposure matrices, we assessed maternal occupational exposure to solvents. Logistic and multiple linear regressions were used to assess the association between maternal occupational solvent exposure and SGA status, birth weight, and HC. Analyses were conducted for exposure during pregnancy and also stratified by the trimester that pregnancy leave began. RESULTS: We observed a higher risk of SGA newborns among mothers occupationally exposed during pregnancy to petroleum solvents (OR(adjusted) = 1.26; 95%CI: 1.01 to 1.57). Among women working until the third trimester of pregnancy, we observed a higher risk of SGA newborns to those occupationally exposed to oxygenated solvents (OR(adjusted) = 1.75; 95%CI: 1.11 to 2.75), a significantly lower birthweight for infants of mothers exposed to petroleum solvents (β(adjusted) = -47.37 g; -89.33 to -5.42), and a lower HC among newborns of those occupationally exposed to oxygenated solvents (β(adjusted) = -0.28; -0.49 to -0.07) and to chlorinated solvents (β(adjusted) = -0.29; -0.53 to -0.05). DISCUSSION: Our results suggest that maternal occupational solvent exposure may influence fetal growth, especially exposure into the third trimester of pregnancy.
dc.language.isoENen_US
dc.title.enMaternal occupational exposure to organic solvents and intrauterine growth in the ELFE cohort
dc.title.alternativeEnviron Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envres.2022.115187en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36587719en_US
bordeaux.journalEnvironmental Researchen_US
bordeaux.volume224
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Research&rft.date=2023-05-01&rft.volume=224&rft.eissn=1096-0953%20(Electronic)%200013-9351%20(Linking)&rft.issn=1096-0953%20(Electronic)%200013-9351%20(Linking)&rft.au=ENDERLE,%20Isabelle&DE%20LAUZUN,%20Virginie%20DE&METTEN,%20Marie-Astrid&MONPERRUS,%20Marion&DELVA,%20Fleur&rft.genre=article


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