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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDAOUD-PINEAU, Frederic
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLETINIER, Louis
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOORE, Nicholas
dc.contributor.authorCOSTE, Pierre
dc.contributor.authorKARJALAINEN, Pasi P
dc.date.accessioned2023-02-02T09:57:21Z
dc.date.available2023-02-02T09:57:21Z
dc.date.issued2022-12-07
dc.identifier.issn2227-9059en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171840
dc.description.abstractEn(1) Background: Practice guidelines define drug-eluting stents (DES) as the standard of care in coronary percutaneous coronary intervention (PCI), including in acute coronary syndrome (ACS). This is based on comparisons with bare-metal stents (BMS). However, non-drug-eluting titanium-nitride-oxide-coated stents (TiNOS) have not been taken into account. The objective of this study is to determine whether TiNOS can be used as an alternative to DES in ACS. (2) Methods: A prospective systematic literature review (SLR), conducted according to the PRISMA guidelines, was performed, wherein multiple literature databases from 2018 and 2022 were searched. Prospective, randomised, controlled trials comparing outcomes after PCI with TiNOS vs. DES in any coronary artery disease (CAD) were searched. Clinical outcomes were meta-analytic pooled risk ratios (RR) of device-oriented Major Adverse Cardiac Events (MACE) and their components. The analysis stratified outcomes reported with ACS-only vs. ACS jointly with chronic coronary syndrome (CCS). (3) Results: Five RCTs were eligible, comprising 1855 patients with TiNOS vs. 1363 with DES at a 1-year follow-up. Three enrolled patients presented with ACS only and two with ACS or CCS. The latter accounted for most of the patients. The one-year pooled RRs in those three RCTs were as follows: MACE 0.93 [0.72, 1.20], recurrent myocardial infarction (MI) 0.48 [0.31, 0.73], cardiac death (CD) 0.66 [0.33, 1.31], clinically driven target lesion revascularization (TLR) 1.55 [1.10, 2.19], and stent thrombosis (ST) 0.35 [0.20, 0.64]. Those results were robust to a sensitivity analysis. The evidence certainty was high in MACE and moderate or low in the other endpoints. (4) Conclusions: TiNOS are a non-inferior and safe alternative to DES in patients with ACS.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enmeta-analysis
dc.subject.enacute coronary syndrome
dc.subject.enpercutaneous coronary intervention
dc.subject.endrug-eluting stents
dc.subject.ennon-drug-eluting titanium-nitride-oxide coated stents (TiNOS)
dc.subject.enMajor Adverse Cardiac Events (MACE)
dc.subject.enrecurrent myocardial infarction
dc.subject.enstent thrombosis
dc.title.enEfficacy and Safety of TiNO-Coated Stents versus Drug-Eluting Stents in Acute Coronary Syndrome: Systematic Literature Review and Meta-Analysis.
dc.title.alternativeBiomedicinesen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/biomedicines10123159en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36551915en_US
bordeaux.journalBiomedicinesen_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03969283
hal.version1
hal.date.transferred2023-02-02T09:57:25Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomedicines&rft.date=2022-12-07&rft.volume=10&rft.issue=12&rft.eissn=2227-9059&rft.issn=2227-9059&rft.au=DAOUD-PINEAU,%20Frederic&LETINIER,%20Louis&MOORE,%20Nicholas&COSTE,%20Pierre&KARJALAINEN,%20Pasi%20P&rft.genre=article


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