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Thalamic nuclei atrophy at high and heterogenous rates during cognitively unimpaired human aging

dc.rights.licenseopenen_US
dc.contributor.authorCHOI, Eun Young
hal.structure.identifierDepartment of Biomedical Data Science [Stanford] [DBDS]
dc.contributor.authorTIAN, Lu
hal.structure.identifierDepartment of Electrical Engineering [Stanford]
hal.structure.identifierDepartment of Radiology [Stanford]
dc.contributor.authorSU, Jason H.
hal.structure.identifierDepartment of Computer Science
dc.contributor.authorRADOVAN, Matthew T.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
hal.structure.identifierDepartment of Psychology [Stanford]
dc.contributor.authorTRAN, Tammy T.
hal.structure.identifierDepartment of Psychology [Stanford]
dc.contributor.authorTRELLE, Alexandra N.
hal.structure.identifierDepartment of Neurology and Neurological Sciences [Stanford]
dc.contributor.authorMORMINO, Elizabeth
hal.structure.identifierDepartment of Neurology and Neurological Sciences [Stanford]
hal.structure.identifierDepartment of Psychology [Stanford]
dc.contributor.authorWAGNER, Anthony D.
hal.structure.identifierDepartment of Radiology [Stanford]
dc.contributor.authorRUTT, Brian K.
dc.date.accessioned2023-01-26T14:42:05Z
dc.date.available2023-01-26T14:42:05Z
dc.date.created2022
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171808
dc.description.abstractEnThe thalamus is a central integration structure in the brain, receiving and distributing information among the cerebral cortex, subcortical structures, and the peripheral nervous system. Prior studies clearly show that the thalamus atrophies in cognitively unimpaired aging. However, the thalamus is comprised of multiple nuclei involved in a wide range of functions, and the age-related atrophy of individual thalamic nuclei remains unknown. Using a recently developed automated method of identifying thalamic nuclei (3T or 7T MRI with white-matter-nulled MPRAGE contrast and THOMAS segmentation) and a cross-sectional design, we evaluated the age-related atrophy rate for 10 thalamic nuclei (AV, CM, VA, VLA, VLP, VPL, pulvinar, LGN, MGN, MD) and an epithalamic nucleus (habenula). We also used T1-weighted images with the FreeSurfer SAMSEG segmentation method to identify and measure age-related atrophy for 11 extra-thalamic structures (cerebral cortex, cerebral white matter, cerebellar cortex, cerebellar white matter, amygdala, hippocampus, caudate, putamen, nucleus accumbens, pallidum, and lateral ventricle). In 198 cognitively unimpaired participants with ages spanning 20–88 years, we found that the whole thalamus atrophied at a rate of 0.45% per year, and that thalamic nuclei had widely varying age-related atrophy rates, ranging from 0.06% to 1.18% per year. A functional grouping analysis revealed that the thalamic nuclei involved in cognitive (AV, MD; 0.53% atrophy per year), visual (LGN, pulvinar; 0.62% atrophy per year), and auditory/vestibular (MGN; 0.64% atrophy per year) functions atrophied at significantly higher rates than those involved in motor (VA, VLA, VLP, and CM; 0.37% atrophy per year) and somatosensory (VPL; 0.32% atrophy per year) functions. A proximity-to-CSF analysis showed that the group of thalamic nuclei situated immediately adjacent to CSF atrophied at a significantly greater atrophy rate (0.59% atrophy per year) than that of the group of nuclei located farther from CSF (0.36% atrophy per year), supporting a growing hypothesis that CSF-mediated factors contribute to neurodegeneration. We did not find any significant hemispheric differences in these rates of change for thalamic nuclei. Only the CM thalamic nucleus showed a sex-specific difference in atrophy rates, atrophying at a greater rate in male versus female participants. Roughly half of the thalamic nuclei showed greater atrophy than all extra-thalamic structures examined (0% to 0.54% per year). These results show the value of white-matter-nulled MPRAGE imaging and THOMAS segmentation for measuring distinct thalamic nuclei and for characterizing the high and heterogeneous atrophy rates of the thalamus and its nuclei across the adult lifespan. Collectively, these methods and results advance our understanding of the role of thalamic substructures in neurocognitive and disease-related changes that occur with aging. © 2022
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAtrophy
dc.subject.enCognitively unimpaired aging
dc.subject.enTHOMAS segmentation
dc.subject.enThalamic nuclei
dc.subject.enThalamus
dc.subject.enWhite matter nulled imaging
dc.title.enThalamic nuclei atrophy at high and heterogenous rates during cognitively unimpaired human aging
dc.title.alternativeNeuroimageen_US
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1016/j.neuroimage.2022.119584en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36007822en_US
bordeaux.page119584en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
bordeaux.identifier.funderIDAlzheimer's Associationen_US
bordeaux.identifier.funderIDWu Tsai Neurosciences Institute, Stanford Universityen_US
hal.identifierhal-03958286
hal.version1
hal.date.transferred2023-01-26T14:42:15Z
hal.exporttrue
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.spage=119584&rft.epage=119584&rft.au=CHOI,%20Eun%20Young&TIAN,%20Lu&SU,%20Jason%20H.&RADOVAN,%20Matthew%20T.&TOURDIAS,%20Thomas&rft.genre=preprint


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