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Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease

dc.rights.licenseopenen_US
dc.contributor.authorLOPEZ-GAMBERO, Antonio J.
dc.contributor.authorPACHECO-SANCHEZ, Beatriz
dc.contributor.authorROSELL-VALLE, Cristina
dc.contributor.authorMEDINA-VERA, Dina
dc.contributor.authorNAVARRO, Juan Antonio
dc.contributor.authorDEL MAR FERNANDEZ-ARJONA, Maria
dc.contributor.authorDE CEGLIA, Marialuisa
dc.contributor.authorSANJUAN, Carlos
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSIMON, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
dc.contributor.authorRIVERA, Patricia
dc.contributor.authorRODRIGUEZ DE FONSECA, Fernando
dc.contributor.authorSUAREZ, Juan
dc.date.accessioned2022-12-20T16:38:34Z
dc.date.available2022-12-20T16:38:34Z
dc.date.issued2022-06
dc.identifier.issn0753-3322en_US
dc.identifier.otherdoi:10.1016/j.biopha.2022.112994en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171586
dc.description.abstractEnIncreasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer's Disease (AD) with sex differences. This study aimed to determine the effect of oral dietary administration of D-Chiro-inositol (DCI), an inositol used against insulin resistance associated with polycystic ovary, on the occurrence of metabolic disorders in the transgenic 5xFAD mouse model of AD (FAD: Family Alzheimer's Disease). DCI was administered from 6 to 10 months of age to male and female 5xFAD mice and control (non-Tg) littermates. Energy balance and multiple metabolic and inflammatory parameters in the hypothalamus, liver and plasma were evaluated to assess the central and peripheral effects of DCI. Results indicated that weight loss and reduced food intake in 5xFAD mice were associated with decreased neuropeptides controlling food intake and the appearance of a pro-inflammatory state in the hypothalamus. Oral administration of DCI partially restored energy balance and hypothalamic parameters, highlighting an increased expression of Npy and Agrp and female-specific downregulation of Gfap and Igf1. DCI also partially normalized impaired insulin signaling and circulating insulin, GLP-1, and GIP deficiencies in 5xFAD mice. Principal component analysis of metabolic parameters indicated the presence of a female-specific fatty liver in 5xFAD mice: DCI administration reversed hepatic fat accumulation, β-oxidation, inflammation and increased GOT and GPT levels. Our study depicts that metabolic impairment along with the cognitive decline in a mouse model of AD, which is exacerbated in females, can be ameliorated by oral supplementation with insulin-sensitizing DCI. © 2022 The Authors
dc.description.sponsorshipRôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité.en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.description.sponsorshipInnovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeuren_US
dc.description.sponsorshipLa signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métaboliqueen_US
dc.description.sponsorshipRôle du circuit POMC-striatum ventral dans le développement de l'obésitéen_US
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAlzheimer’s disease
dc.subject.enD-chiro-inositol
dc.subject.enFatty liver disease
dc.subject.enHypothalamus
dc.subject.enInflammation
dc.subject.enInsulin signaling
dc.title.enDietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer's disease
dc.title.alternativeBiomed Pharmacotheren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biopha.2022.112994en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35483188en_US
dc.description.sponsorshipEuropeDefining a Roadmap for Cooperative Health research between the EU and Latin America-Caribbean countries: a Policy Oriented Approachen_US
bordeaux.journalBiomedicine & pharmacotherapyen_US
bordeaux.page112994en_US
bordeaux.volume150en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDEuropean Regional Development Funden_US
bordeaux.identifier.funderIDMinisterio de Economía y Competitividaden_US
bordeaux.identifier.funderIDInstituto de Salud Carlos IIIen_US
hal.identifierhal-03908669
hal.version1
hal.date.transferred2022-12-20T16:38:51Z
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomedicine%20&%20pharmacotherapy&rft.date=2022-06&rft.volume=150&rft.spage=112994&rft.epage=112994&rft.eissn=0753-3322&rft.issn=0753-3322&rft.au=LOPEZ-GAMBERO,%20Antonio%20J.&PACHECO-SANCHEZ,%20Beatriz&ROSELL-VALLE,%20Cristina&MEDINA-VERA,%20Dina&NAVARRO,%20Juan%20Antonio&rft.genre=article


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