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Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

dc.rights.licenseopenen_US
dc.contributor.authorJANSEN, Iris E.
dc.contributor.authorVAN DER LEE, Sven J
dc.contributor.authorGOMEZ-FONSECA, Duber
dc.contributor.authorDE ROJAS, Itziar
dc.contributor.authorDALMASSO, Maria Carolina
dc.contributor.authorGRENIER-BOLEY, Benjamin
dc.contributor.authorZETTERGREN, Anna
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorALI, Muhammad
dc.contributor.authorANDRADE, Victor
dc.contributor.authorBELLENGUEZ, Celine
dc.contributor.authorKLEINEIDAM, Luca
dc.contributor.authorKUCUKALI, Fahri
dc.contributor.authorSUNG, Yun Ju
dc.contributor.authorTESI, Niccolo
dc.contributor.authorVROMEN, Ellen M.
dc.contributor.authorWIGHTMAN, Douglas P.
dc.contributor.authorALCOLEA, Daniel
dc.contributor.authorALEGRET, Montserrat
dc.contributor.authorALVAREZ, Ignacio
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorATHANASIU, Lavinia
dc.contributor.authorBAHRAMI, Shahram
dc.contributor.authorBAILLY, Henri
dc.contributor.authorBELBIN, Olivia
dc.contributor.authorBERGH, Sverre
dc.contributor.authorBERTRAM, Lars
dc.contributor.authorBIESSELS, Geert Jan
dc.contributor.authorBLENNOW, Kaj
dc.contributor.authorBLESA, Rafael
dc.contributor.authorBOADA, Merce
dc.contributor.authorBOLAND, Anne
dc.contributor.authorBUERGER, Katharina
dc.contributor.authorCARRACEDO, Angel
dc.contributor.authorCERVERA-CARLES, Laura
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
dc.contributor.authorCLAASSEN, Jurgen A. H. R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDELEUZE, Jean-Francois
dc.contributor.authorDE DEYN, Peter Paul
dc.contributor.authorDIEHL-SCHMID, Janine
dc.contributor.authorDJUROVIC, Srdjan
dc.contributor.authorDOLS-ICARDO, Oriol
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorDURON, Emmanuelle
dc.contributor.authorDUZEL, Emrah
dc.contributor.authorFLADBY, Tormod
dc.contributor.authorFORTEA, Juan
dc.contributor.authorFROLICH, Lutz
dc.contributor.authorGARCIA-GONZALEZ, Pablo
dc.contributor.authorGARCIA-MARTINEZ, Maria
dc.contributor.authorGIEGLING, Ina
dc.contributor.authorGOLDHARDT, Oliver
dc.contributor.authorGOBOM, Johan
dc.contributor.authorGRIMMER, Timo
dc.contributor.authorHAAPASALO, Annakaisa
dc.contributor.authorHAMPEL, Harald
dc.contributor.authorHANON, Olivier
dc.contributor.authorHAUSNER, Lucrezia
dc.contributor.authorHEILMANN-HEIMBACH, Stefanie
dc.contributor.authorHELISALMI, Seppo
dc.contributor.authorHENEKA, Michael T.
dc.contributor.authorHERNANDEZ, Isabel
dc.contributor.authorHERUKKA, Sanna-Kaisa
dc.contributor.authorHOLSTEGE, Henne
dc.contributor.authorJARHOLM, Jonas
dc.contributor.authorKERN, Silke
dc.contributor.authorKNAPSKOG, Anne-Brita
dc.contributor.authorKOIVISTO, Anne M.
dc.contributor.authorKORNHUBER, Johannes
dc.contributor.authorKUULASMAA, Teemu
dc.contributor.authorLAGE, Carmen
dc.contributor.authorLASKE, Christoph
dc.contributor.authorLEINONEN, Ville
dc.contributor.authorLEWCZUK, Piotr
dc.contributor.authorLLEO, Alberto
dc.contributor.authorDE MUNAIN, Adolfo Lopez
dc.contributor.authorLOPEZ-GARCIA, Sara
dc.contributor.authorMAIER, Wolfgang
dc.contributor.authorMARQUIE, Marta
dc.contributor.authorMOL, Merel O.
dc.contributor.authorMONTRREAL, Laura
dc.contributor.authorMORENO, Fermin
dc.contributor.authorMORENO-GRAU, Sonia
dc.contributor.authorNICOLAS, Gael
dc.contributor.authorNOTHEN, Markus M
dc.contributor.authorORELLANA, Adelina
dc.contributor.authorPALHAUGEN, Lene
dc.contributor.authorPAPMA, Janne M.
dc.contributor.authorPASQUIER, Florence
dc.contributor.authorPERNECZKY, Robert
dc.contributor.authorPETERS, Oliver
dc.contributor.authorPIJNENBURG, Yolande A. L.
dc.contributor.authorPOPP, Julius
dc.contributor.authorPOSTHUMA, Danielle
dc.contributor.authorPOZUETA, Ana
dc.contributor.authorPRILLER, Josef
dc.contributor.authorPUERTA, Raquel
dc.contributor.authorQUINTELA, Ines
dc.contributor.authorRAMAKERS, Inez
dc.contributor.authorRODRIGUEZ-RODRIGUEZ, Eloy
dc.contributor.authorRUJESCU, Dan
dc.contributor.authorSALTVEDT, Ingvild
dc.contributor.authorSANCHEZ-JUAN, Pascual
dc.contributor.authorSCHELTENS, Philip
dc.contributor.authorSCHERBAUM, Norbert
dc.contributor.authorSCHMID, Matthias
dc.contributor.authorSCHNEIDER, Anja
dc.contributor.authorSELBAEK, Geir
dc.contributor.authorSELNES, Per
dc.contributor.authorSHADRIN, Alexey
dc.contributor.authorSKOOG, Ingmar
dc.contributor.authorSOININEN, Hilkka
dc.contributor.authorTARRAGA, Lluis
dc.contributor.authorTEIPEL, Stefan
dc.contributor.authorTIJMS, Betty
dc.contributor.authorTSOLAKI, Magda
dc.contributor.authorVAN BROECKHOVEN, Christine
dc.contributor.authorVAN DONGEN, Jasper
dc.contributor.authorVAN SWIETEN, John C.
dc.contributor.authorVANDENBERGHE, Rik
dc.contributor.authorVIDAL, Jean-Sebastien
dc.contributor.authorVISSER, Pieter J.
dc.contributor.authorVOGELGSANG, Jonathan
dc.contributor.authorWAERN, Margda
dc.contributor.authorWAGNER, Michael
dc.contributor.authorWILTFANG, Jens
dc.contributor.authorWITTENS, Mandy M. J.
dc.contributor.authorZETTERBERG, Henrik
dc.contributor.authorZULAICA, Miren
dc.contributor.authorVAN DUIJN, Cornelia M.
dc.contributor.authorBJERKE, Maria
dc.contributor.authorENGELBORGHS, Sebastiaan
dc.contributor.authorJESSEN, Frank
dc.contributor.authorTEUNISSEN, Charlotte E.
dc.contributor.authorPASTOR, Pau
dc.contributor.authorHILTUNEN, Mikko
dc.contributor.authorINGELSSON, Martin
dc.contributor.authorANDREASSEN, Ole A.
dc.contributor.authorCLARIMON, Jordi
dc.contributor.authorSLEEGERS, Kristel
dc.contributor.authorRUIZ, Agustin
dc.contributor.authorRAMIREZ, Alfredo
dc.contributor.authorCRUCHAGA, Carlos
dc.contributor.authorLAMBERT, Jean-Charles
dc.contributor.authorVAN DER FLIER, Wiesje
dc.date.accessioned2022-12-16T09:25:40Z
dc.date.available2022-12-16T09:25:40Z
dc.date.issued2022-11
dc.identifier.issn1432-0533 (Electronic) 0001-6322 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171541
dc.description.abstractEnAmyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aβ42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enGWAS
dc.subject.enAlzheimer’s disease
dc.subject.enCerebrospinal fluid
dc.subject.enAmyloid-beta
dc.subject.enTau
dc.title.enGenome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00401-022-02454-zen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36066633en_US
bordeaux.journalActa Neuropathologicaen_US
bordeaux.page821-842en_US
bordeaux.volume144en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamPHARES_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03902957
hal.version1
hal.date.transferred2022-12-16T09:26:27Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20Neuropathologica&rft.date=2022-11&rft.volume=144&rft.issue=5&rft.spage=821-842&rft.epage=821-842&rft.eissn=1432-0533%20(Electronic)%200001-6322%20(Linking)&rft.issn=1432-0533%20(Electronic)%200001-6322%20(Linking)&rft.au=JANSEN,%20Iris%20E.&VAN%20DER%20LEE,%20Sven%20J&GOMEZ-FONSECA,%20Duber&DE%20ROJAS,%20Itziar&DALMASSO,%20Maria%20Carolina&rft.genre=article


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