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dc.rights.licenseopenen_US
hal.structure.identifierAchucarro Basque Center for Neuroscience [Leioa, Spain] [ABCN]
dc.contributor.authorBARAIBAR, Andre M.
hal.structure.identifierUniversity of Minnesota [Minneapolis, USA]
dc.contributor.authorBELISLE, Lindsey
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
hal.structure.identifierAchucarro Basque Center for Neuroscience [Leioa, Spain] [ABCN]
dc.contributor.authorMATUTE, Carlos
hal.structure.identifierAchucarro Basque Center for Neuroscience [Leioa, Spain] [ABCN]
dc.contributor.authorMATO, Susana
hal.structure.identifierUniversity of Minnesota [Minneapolis, USA]
dc.contributor.authorARAQUE, Alfonso
hal.structure.identifierUniversity of Minnesota [Minneapolis, USA]
dc.contributor.authorKOFUJI, Paulo
dc.date.accessioned2022-12-09T12:50:28Z
dc.date.available2022-12-09T12:50:28Z
dc.date.created2022-02-05
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170550
dc.description.abstractEnMicrocircuits in the neocortex are functionally organized along layers and columns, which are the fundamental modules of cortical information processing. While the function of cortical microcircuits has focused on neuronal elements, much less is known about the functional organization of astrocytes and their bidirectional interaction with neurons. Here, we show that Cannabinoid type 1 receptor (CB1R)-mediated astrocyte activation by neuron-released endocannabinoids elevate astrocyte Ca2+ levels, stimulate ATP/adenosine release as gliotransmitters, and transiently depress synaptic transmission in layer 5 pyramidal neurons at relatively distant synapses (˃20 μm) from the stimulated neuron. This astrocyte-mediated heteroneuronal synaptic depression occurred between pyramidal neurons within a cortical column and was absent in neurons belonging to adjacent cortical columns. Moreover, this form of heteroneuronal synaptic depression occurs between neurons located in particular layers, following a specific connectivity pattern that depends on a layer-specific neuron-to-astrocyte signaling. These results unravel the existence of astrocyte-mediated nonsynaptic communication between cortical neurons and that this communication is column- and layer-specific, which adds further complexity to the intercellular signaling processes in the neocortex.
dc.language.isoENen_US
dc.subject.enAstrocyte
dc.subject.enCalcium imaging
dc.subject.enCortex
dc.subject.enNeuron-astrocyte communication
dc.subject.enSynaptic transmission
dc.title.enSpatial organization of neuron-astrocyte interactions in the somatosensory cortex.
dc.title.alternativeCereb Cortexen_US
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1093/cercor/bhac357en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36124663en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03891819
hal.version1
hal.date.transferred2022-12-09T12:50:32Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=BARAIBAR,%20Andre%20M.&BELISLE,%20Lindsey&MARSICANO,%20Giovanni&MATUTE,%20Carlos&MATO,%20Susana&rft.genre=preprint


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