Vangl2, a core component of the WNT/PCP pathway, regulates adult hippocampal neurogenesis and age-related decline in cognitive flexibility
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | KOEHL, Muriel | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LADEVEZE, Elodie | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MONTCOUQUIOL, Mireille | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | ABROUS, Nora | |
| dc.date.accessioned | 2022-12-08T11:11:13Z | |
| dc.date.available | 2022-12-08T11:11:13Z | |
| dc.date.issued | 2022-03-09 | |
| dc.identifier.issn | 1663-4365 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170503 | |
| dc.description.abstractEn | Decline in episodic memory is one of the hallmarks of aging and represents one of the most important health problems facing western societies. A key structure in episodic memory is the hippocampal formation and the dentate gyrus in particular, as the continuous production of new dentate granule neurons in this brain region was found to play a crucial role in memory and in age-related decline in memory. As such, understanding the molecular processes that regulate the relationship between adult neurogenesis and aging of memory function holds great therapeutic potential. Recently, we found that Vang-gogh like 2 (Vangl2), a core component of the planar cell polarity signaling pathway, is enriched in the dentate gyrus of adult mice. In this context, we sought to evaluate the involvement of this effector of the Wnt/PCP pathway in both adult neurogenesis and memory abilities in adult and middle-aged mice. Using a heterozygous mouse model carrying a dominant negative mutation in Vangl2 gene, we show that alteration in Vangl2 expression decreases the survival of adult-born granule cells and advances the onset of decrease in cognitive flexibility. Inability of mutant mice to erase old irrelevant information to the benefit of new relevant ones highlights a key role of Vangl2 in interference-based forgetting. Taken together, our findings show for the first that Vangl2 activity may constitute an interesting target to prevent age-related decline in hippocampal plasticity and memory. | |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.description.sponsorship | Neurogénèse hippocampique: un nouveau substrat de la mémoire - ANR-10-BLAN-1408 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Vangl2 mutation accelerates cognitive aging adult neurogenesis | |
| dc.subject.en | hippocampus | |
| dc.subject.en | Vangl2 | |
| dc.subject.en | planar cell polarity | |
| dc.subject.en | memory | |
| dc.subject.en | forgetting | |
| dc.subject.en | flexibility | |
| dc.subject.en | interferences | |
| dc.title.en | Vangl2, a core component of the WNT/PCP pathway, regulates adult hippocampal neurogenesis and age-related decline in cognitive flexibility | |
| dc.title.alternative | Front Aging Neurosci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fnagi.2022.844255 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35370613 | en_US |
| bordeaux.journal | Frontiers in Aging Neuroscience | en_US |
| bordeaux.page | 844255 | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Neurogénèse et physiopathologie | en_US |
| bordeaux.team | Polarité planaire et plasticité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03373559 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY | en_US |
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