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Brain imaging determinants of functional prognosis after severe endocarditis: a multicenter observational study

dc.rights.licenseopenen_US
dc.contributor.authorGUETTARD, Yves Olivier
dc.contributor.authorGROS, Alexandre
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFUKUTOMI, Hikaru
dc.contributor.authorPILLOIS, Xavier
dc.contributor.authorPREAU, Sebastien
dc.contributor.authorLAVIE-BADIE, Yoan
dc.contributor.authorMAREST, Delphine
dc.contributor.authorMARTINS, Raphael P.
dc.contributor.authorCOUPEZ, Elisabeth
dc.contributor.authorCOUDROY, Remi
dc.contributor.authorSEGUY, Benjamin
dc.contributor.authorBOYER, Alexandre
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
dc.date.accessioned2022-12-02T08:39:46Z
dc.date.available2022-12-02T08:39:46Z
dc.date.issued2022-06
dc.identifier.issn1590-1874en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170448
dc.description.abstractEnObjective: We developed a detailed imaging phenotype of the cerebral complications in critically ill patients with infective endocarditis (IE) and determine whether any specific imaging pattern could impact prognostic information. Methods: One hundred ninety-two patients admitted to the intensive care units of seven tertiary centers with severe, definite left IE and neurological complications were included. All underwent cerebral imaging few days after admission to define the types of lesions, their volumes, and their locations using voxel-based lesion-symptom mapping (VLSM). We employed uni- and multi-variate logistic regression analyses to explore the associations among imaging features and other prognostic variables and the 6-month modified Rankin Scale (mRS) score. Results: Ischemic lesions were the most common lesions (75%; mean volume, 15.3 ± 33 mL) followed by microbleeds (50%; mean number, 4 ± 7.5), subarachnoidal hemorrhages (20%), hemorrhagic strokes (16%; mean volume, 14.6 ± 21 mL), and hemorrhagic transformations (10%; mean volume, 5.6 ± 11 mL). The volume of hemorrhagic transformations, the severity of leukopathy, and the compromises of certain locations on the motor pathway from the VLSM were associated with a poor 6-month mRS score on univariate analyses. However, upon multivariate analyses, no such specific imaging pattern independently predicted the mRS; this was instead influenced principally by age (OR = 1.03 [1.004–1.06]) and cardiac surgery status (OR = 0.06 [0.02–0.16]) in the entire cohort, and by age (OR = 1.04 [1.01–1.08]) and Staphylococcus aureus status (OR = 2.86 [1.19–6.89]) in operated patients. Conclusions: In a cohort of severely ill IE patients with neurological complications, no specific imaging pattern could be highlighted as a reliable predictor of prognosis. © 2021, Fondazione Società Italiana di Neurologia.
dc.language.isoENen_US
dc.subject.enInfective endocarditis
dc.subject.enStroke
dc.subject.enTopography
dc.subject.enPrognosis
dc.title.enBrain imaging determinants of functional prognosis after severe endocarditis: a multicenter observational study
dc.title.alternativeNeurol Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10072-021-05789-9en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35091884en_US
bordeaux.journalNeurological Sciencesen_US
bordeaux.page3759-3768en_US
bordeaux.volume43en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurological%20Sciences&rft.date=2022-06&rft.volume=43&rft.issue=6&rft.spage=3759-3768&rft.epage=3759-3768&rft.eissn=1590-1874&rft.issn=1590-1874&rft.au=GUETTARD,%20Yves%20Olivier&GROS,%20Alexandre&FUKUTOMI,%20Hikaru&PILLOIS,%20Xavier&PREAU,%20Sebastien&rft.genre=article


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