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Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke

dc.rights.licenseopenen_US
dc.contributor.authorJAWOREK, Thomas
dc.contributor.authorXU, Huichun
dc.contributor.authorGAYNOR, Brady J.
dc.contributor.authorCOLE, John W.
dc.contributor.authorRANNIKMAE, Kristiina
dc.contributor.authorSTANNE, Tara M.
dc.contributor.authorTOMPPO, Liisa
dc.contributor.authorABEDI, Vida
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorARMSTRONG, Nicole D.
dc.contributor.authorATTIA, John
dc.contributor.authorBELL, Steven
dc.contributor.authorBENAVENTE, Oscar R.
dc.contributor.authorBONCORAGLIO, Giorgio B.
dc.contributor.authorBUTTERWORTH, Adam
dc.contributor.authorCARCEL-MARQUEZ, Jara
dc.contributor.authorCHEN, Zhengming
dc.contributor.authorCHONG, Michael
dc.contributor.authorCRUCHAGA, Carlos
dc.contributor.authorCUSHMAN, Mary
dc.contributor.authorDANESH, John
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDUGGAN, David J.
dc.contributor.authorDURDA, Jon Peter
dc.contributor.authorENGSTROM, Gunnar
dc.contributor.authorENZINGER, Chris
dc.contributor.authorFAUL, Jessica D.
dc.contributor.authorFECTEAU, Natalie S.
dc.contributor.authorFERNANDEZ-CADENAS, Israel
dc.contributor.authorGIEGER, Christian
dc.contributor.authorGIESE, Anne-Katrin
dc.contributor.authorGREWAL, Raji P.
dc.contributor.authorGRITTNER, Ulrike
dc.contributor.authorHAVULINNA, Aki S.
dc.contributor.authorHEITSCH, Laura
dc.contributor.authorHOCHBERG, Marc C.
dc.contributor.authorHOLLIDAY, Elizabeth
dc.contributor.authorHU, Jie
dc.contributor.authorILINCA, Andreea
dc.contributor.authorIRVIN, Marguerite R.
dc.contributor.authorJACKSON, Rebecca D.
dc.contributor.authorJACOB, Mina A.
dc.contributor.authorJANSSEN, Raquel Rabionet
dc.contributor.authorJIMENEZ-CONDE, Jordi
dc.contributor.authorJOHNSON, Julie A.
dc.contributor.authorKAMATANI, Yoichiro
dc.contributor.authorKARDIA, Sharon L.
dc.contributor.authorKOIDO, Masaru
dc.contributor.authorKUBO, Michiaki
dc.contributor.authorLANGE, Leslie
dc.contributor.authorLEE, Jin-Moo
dc.contributor.authorLEMMENS, Robin
dc.contributor.authorLEVI, Christopher R.
dc.contributor.authorLI, Jiang
dc.contributor.authorLI, Liming
dc.contributor.authorLIN, Kuang
dc.contributor.authorLOPEZ, Haley
dc.contributor.authorLUKE, Sothear
dc.contributor.authorMAGUIRE, Jane
dc.contributor.authorMCARDLE, Patrick F.
dc.contributor.authorMCDONOUGH, Caitrin W.
dc.contributor.authorMESCHIA, James F.
dc.contributor.authorMETSO, Tiina
dc.contributor.authorMULLER-NURASYID, Martina
dc.contributor.authorO'CONNOR, Timothy D.
dc.contributor.authorO'DONNELL, Martin
dc.contributor.authorPEDDAREDDYGARI, Leema R.
dc.contributor.authorPERA, Joanna
dc.contributor.authorPERRY, James A.
dc.contributor.authorPETERS, Annette
dc.contributor.authorPUTAALA, Jukka
dc.contributor.authorRAY, Debashree
dc.contributor.authorREXRODE, Kathryn
dc.contributor.authorRIBASES, Marta
dc.contributor.authorROSAND, Jonathan
dc.contributor.authorROTHWELL, Peter M.
dc.contributor.authorRUNDEK, Tatjana
dc.contributor.authorRYAN, Kathleen A.
dc.contributor.authorSACCO, Ralph L.
dc.contributor.authorSALOMAA, Veikko
dc.contributor.authorSANCHEZ-MORA, Cristina
dc.contributor.authorSCHMIDT, Reinhold
dc.contributor.authorSHARMA, Pankaj
dc.contributor.authorSLOWIK, Agnieszka
dc.contributor.authorSMITH, Jennifer A.
dc.contributor.authorSMITH, Nicholas L.
dc.contributor.authorWASSERTHEIL-SMOLLER, Sylvia
dc.contributor.authorSOEDERHOLM, Martin
dc.contributor.authorSTINE, O. C.
dc.contributor.authorSTRBIAN, Daniel
dc.contributor.authorSUDLOW, Cathie L.
dc.contributor.authorTATLISUMAK, Turgut
dc.contributor.authorTERAO, Chikashi
dc.contributor.authorTHIJS, Vincent
dc.contributor.authorTORRES-AGUILA, Nuria P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorTULADHAR, Anil M.
dc.contributor.authorVELDINK, Jan H.
dc.contributor.authorWALTERS, Robin G.
dc.contributor.authorWEIR, David R.
dc.contributor.authorWOO, Daniel
dc.contributor.authorWORRALL, Bradford B.
dc.contributor.authorHONG, Charles C.
dc.contributor.authorROSS, Owen
dc.contributor.authorZAND, Ramin
dc.contributor.authorLEEUW, Frank-Erik De
dc.contributor.authorLINDGREN, Arne G.
dc.contributor.authorPARE, Guillaume
dc.contributor.authorANDERSON, Christopher D.
dc.contributor.authorMARKUS, Hugh S.
dc.contributor.authorJERN, Christina
dc.contributor.authorMALIK, Rainer
dc.contributor.authorDICHGANS, Martin
dc.contributor.authorMITCHELL, Braxton D.
dc.contributor.authorKITTNER, Steven J.
dc.contributor.authorARLY ONSET STROKE GENETICS CONSORTIUM OF THE INTERNATIONAL STROKE GENETICS, Consortium
dc.date.accessioned2022-11-29T08:50:42Z
dc.date.available2022-11-29T08:50:42Z
dc.date.issued2022-08-31
dc.identifier.issn1526-632X (Electronic) 0028-3878 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170414
dc.description.abstractEnBACKGROUND AND OBJECTIVES: Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke. METHODS: We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level data or summary statistics in 16,730 cases and 599,237 non-stroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late onset stroke (LOS) and compared polygenic risk scores for venous thromboembolism between EOS and LOS. RESULTS: We observed genome-wide significant associations of EOS with two variants in ABO, a known stroke locus. These variants tag blood subgroups O1 and A1, and the effect sizes of both variants were significantly larger in EOS compared to LOS. The odds ratio (OR) for rs529565, tagging O1, 0.88 (95% CI: 0.85-0.91) in EOS vs 0.96 (95% CI: 0.92-1.00) in LOS, and the OR for rs635634, tagging A1, was 1.16 (1.11-1.21) for EOS vs 1.05 (0.99-1.11) in LOS; p-values for interaction = 0.001 and 0.005, respectively. Using polygenic risk scores, we observed that greater genetic risk for venous thromboembolism, another prothrombotic condition, was more strongly associated with EOS compared to LOS (p=0.008). DISCUSSION: The ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with EOS than with LOS, supporting a stronger role of prothrombotic factors in EOS.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectInfarction
dc.subjectAssociation studies in genetics
dc.subjectStroke in young adults
dc.title.enContribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000201006en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36240095en_US
bordeaux.journalNeurologyen_US
bordeaux.volume99en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue16en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03877027
hal.version1
hal.date.transferred2022-11-29T08:51:33Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurology&rft.date=2022-08-31&rft.volume=99&rft.issue=16&rft.eissn=1526-632X%20(Electronic)%200028-3878%20(Linking)&rft.issn=1526-632X%20(Electronic)%200028-3878%20(Linking)&rft.au=JAWOREK,%20Thomas&XU,%20Huichun&GAYNOR,%20Brady%20J.&COLE,%20John%20W.&RANNIKMAE,%20Kristiina&rft.genre=article


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