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Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

dc.rights.licenseopenen_US
dc.contributor.authorBERNDT, Sonja I.
dc.contributor.authorVIJAI, Joseph
dc.contributor.authorBENAVENTE, Yolanda
dc.contributor.authorCAMP, Nicola J
dc.contributor.authorNIETERS, Alexandra
dc.contributor.authorWANG, Zhaoming
dc.contributor.authorSMEDBY, Karin E.
dc.contributor.authorKLEINSTERN, Geffen
dc.contributor.authorHJALGRIM, Henrik
dc.contributor.authorBESSON, Caroline
dc.contributor.authorSKIBOLA, Christine F.
dc.contributor.authorMORTON, Lindsay M.
dc.contributor.authorBROOKS-WILSON, Angela R.
dc.contributor.authorTERAS, Lauren R.
dc.contributor.authorBREEZE, Charles
dc.contributor.authorARIAS, Joshua
dc.contributor.authorADAMI, Hans-Olov
dc.contributor.authorALBANES, Demetrius
dc.contributor.authorANDERSON, Kenneth C.
dc.contributor.authorANSELL, Stephen M.
dc.contributor.authorBASSIG, Bryan
dc.contributor.authorBECKER, Nikolaus
dc.contributor.authorBHATTI, Parveen
dc.contributor.authorBIRMANN, Brenda M.
dc.contributor.authorBOFFETTA, Paolo
dc.contributor.authorBRACCI, Paige M
dc.contributor.authorBRENNAN, Paul
dc.contributor.authorBROWN, Elizabeth E.
dc.contributor.authorBURDETT, Laurie
dc.contributor.authorCANNON-ALBRIGHT, Lisa A.
dc.contributor.authorCHANG, Ellen T.
dc.contributor.authorCHIU, Brian C. H.
dc.contributor.authorCHUNG, Charles C.
dc.contributor.authorCLAVEL, Jacqueline
dc.contributor.authorCOCCO, Pierluigi
dc.contributor.authorCOLDITZ, Graham
dc.contributor.authorCONDE, Lucia
dc.contributor.authorCONTI, David V.
dc.contributor.authorCOX, David G.
dc.contributor.authorCURTIN, Karen
dc.contributor.authorCASABONNE, Delphine
dc.contributor.authorDE VIVO, Immaculata
dc.contributor.authorDIVER, W. Ryan
dc.contributor.authorDOGAN, Ahmet
dc.contributor.authorEDLUND, Christopher K.
dc.contributor.authorFORETOVA, Lenka
dc.contributor.authorFRAUMENI, Joseph F. Jr
dc.contributor.authorGABBAS, Attilio
dc.contributor.authorGHESQUIERES, Herve
dc.contributor.authorGILES, Graham G.
dc.contributor.authorGLASER, Sally
dc.contributor.authorGLENN, Martha
dc.contributor.authorGLIMELIUS, Bengt
dc.contributor.authorGU, Jian
dc.contributor.authorHABERMANN, Thomas M.
dc.contributor.authorHAIMAN, Christopher A.
dc.contributor.authorHAIOUN, Corinne
dc.contributor.authorHOFMANN, Jonathan N.
dc.contributor.authorHOLFORD, Theodore R.
dc.contributor.authorHOLLY, Elizabeth A.
dc.contributor.authorHUTCHINSON, Amy
dc.contributor.authorIZHAR, Aalin
dc.contributor.authorJACKSON, Rebecca D.
dc.contributor.authorJARRETT, Ruth F.
dc.contributor.authorKAAKS, Rudolph
dc.contributor.authorKANE, Eleanor
dc.contributor.authorKOLONEL, Laurence N.
dc.contributor.authorKONG, Yinfei
dc.contributor.authorKRAFT, Peter
dc.contributor.authorKRICKER, Anne
dc.contributor.authorLAKE, Annette
dc.contributor.authorLAN, Qing
dc.contributor.authorLAWRENCE, Charles
dc.contributor.authorLI, Dalin
dc.contributor.authorLIEBOW, Mark
dc.contributor.authorLINK, Brian K.
dc.contributor.authorMAGNANI, Corrado
dc.contributor.authorMAYNADIE, Marc
dc.contributor.authorMCKAY, James
dc.contributor.authorMELBYE, Mads
dc.contributor.authorMILIGI, Lucia
dc.contributor.authorMILNE, Roger L.
dc.contributor.authorMOLINA, Thierry J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorMONTALVAN, Rebecca
dc.contributor.authorNORTH, Kari E.
dc.contributor.authorNOVAK, Anne J.
dc.contributor.authorONEL, Kenan
dc.contributor.authorPURDUE, Mark P.
dc.contributor.authorRAND, Kristin A.
dc.contributor.authorRIBOLI, Elio
dc.contributor.authorRIBY, Jacques
dc.contributor.authorROMAN, Eve
dc.contributor.authorSALLES, Gilles
dc.contributor.authorSBOROV, Douglas W.
dc.contributor.authorSEVERSON, Richard K.
dc.contributor.authorSHANAFELT, Tait D.
dc.contributor.authorSMITH, Martyn T.
dc.contributor.authorSMITH, Alexandra
dc.contributor.authorSONG, Kevin W.
dc.contributor.authorSONG, Lei
dc.contributor.authorSOUTHEY, Melissa C.
dc.contributor.authorSPINELLI, John J.
dc.contributor.authorSTAINES, Anthony
dc.contributor.authorSTEPHENS, Deborah
dc.contributor.authorSUTHERLAND, Heather J.
dc.contributor.authorTKACHUK, Kaitlyn
dc.contributor.authorTHOMPSON, Carrie A.
dc.contributor.authorTILLY, Herve
dc.contributor.authorTINKER, Lesley F.
dc.contributor.authorTRAVIS, Ruth C.
dc.contributor.authorTURNER, Jenny
dc.contributor.authorVACHON, Celine M.
dc.contributor.authorVAJDIC, Claire M.
dc.contributor.authorVAN DEN BERG, Anke
dc.contributor.authorVAN DEN BERG, David J.
dc.contributor.authorVERMEULEN, Roel C. H.
dc.contributor.authorVINEIS, Paolo
dc.contributor.authorWANG, Sophia S.
dc.contributor.authorWEIDERPASS, Elisabete
dc.contributor.authorWEINER, George J.
dc.contributor.authorWEINSTEIN, Stephanie
dc.contributor.authorDOO, Nicole Wong
dc.contributor.authorYE, Yuanqing
dc.contributor.authorYEAGER, Meredith
dc.contributor.authorYU, Kai
dc.contributor.authorZELENIUCH-JACQUOTTE, Anne
dc.contributor.authorZHANG, Yawei
dc.contributor.authorZHENG, Tongzhang
dc.contributor.authorZIV, Elad
dc.contributor.authorSAMPSON, Joshua
dc.contributor.authorCHATTERJEE, Nilanjan
dc.contributor.authorOFFIT, Kenneth
dc.contributor.authorCOZEN, Wendy
dc.contributor.authorWU, Xifeng
dc.contributor.authorCERHAN, James R.
dc.contributor.authorCHANOCK, Stephen J.
dc.contributor.authorSLAGER, Susan L.
dc.contributor.authorROTHMAN, Nathaniel
dc.date.accessioned2022-11-28T13:39:41Z
dc.date.available2022-11-28T13:39:41Z
dc.date.issued2022-10-22
dc.identifier.issn1476-5551 (Electronic) 0887-6924 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170403
dc.description.abstractEnLymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10(-8)) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10(-9)). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10(-8)), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
dc.language.isoENen_US
dc.title.enDistinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41375-022-01711-0en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36273105en_US
bordeaux.journalLeukemiaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03875563
hal.version1
hal.date.transferred2022-11-28T13:40:30Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Leukemia&amp;rft.date=2022-10-22&amp;rft.eissn=1476-5551%20(Electronic)%200887-6924%20(Linking)&amp;rft.issn=1476-5551%20(Electronic)%200887-6924%20(Linking)&amp;rft.au=BERNDT,%20Sonja%20I.&amp;VIJAI,%20Joseph&amp;BENAVENTE,%20Yolanda&amp;CAMP,%20Nicola%20J&amp;NIETERS,%20Alexandra&amp;rft.genre=article


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