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Expression of Functional Cannabinoid Type-1 (CB1) Receptor in Mitochondria of White Adipocytes
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | PAGANO ZOTTOLA, Antonio C. | |
| dc.contributor.author | SEVERI, Ilenia | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CANNICH, Astrid | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CIOFI, Philippe | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARSICANO, Giovanni | |
| dc.contributor.author | GIORDANO, Antonio | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BELLOCCHIO, Luigi | |
| dc.date.accessioned | 2022-11-18T13:37:49Z | |
| dc.date.available | 2022-11-18T13:37:49Z | |
| dc.date.issued | 2022-08-19 | |
| dc.identifier.issn | 2073-4409 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170324 | |
| dc.description.abstractEn | Via activation of the cannabinoid type-1 (CB1) receptor, endogenous and exogenous cannabinoids modulate important biochemical and cellular processes in adipocytes. Several pieces of evidence suggest that alterations of mitochondrial physiology might be a possible mechanism underlying cannabinoids’ effects on adipocyte biology. Many reports suggest the presence of CB1 receptor mRNA in both white and brown adipose tissue, but the detailed subcellular localization of CB1 protein in adipose cells has so far been scarcely addressed. In this study, we show the presence of the functional CB1 receptor at different subcellular locations of adipocytes from epididymal white adipose tissue (eWAT) depots. We observed that CB1 is located at different subcellular levels, including the plasma membrane and in close association with mitochondria (mtCB1). Functional analysis in tissue homogenates and isolated mitochondria allowed us to reveal that cannabinoids negatively regulate complex-I-dependent oxygen consumption in eWAT. This effect requires mtCB1 activation and consequent regulation of the intramitochondrial cAMP-PKA pathway. Thus, CB1 receptors are functionally present at the mitochondrial level in eWAT adipocytes, adding another possible mechanism for peripheral regulation of energy metabolism. © 2022 by the authors. | |
| dc.description.sponsorship | Role du recepteur CB1 mitocondriel du tissue adipeux dans la regulation de la balance energetique | en_US |
| dc.description.sponsorship | Vieillissement et démence: un rôle hormonal? - ANR-17-CE16-0015 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | CB1 receptor | |
| dc.subject.en | Mitochondria | |
| dc.subject.en | White adipose tissue | |
| dc.title.en | Expression of Functional Cannabinoid Type-1 (CB1) Receptor in Mitochondria of White Adipocytes | |
| dc.title.alternative | Cells | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/cells11162582 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 36010658 | en_US |
| dc.description.sponsorshipEurope | Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes | en_US |
| bordeaux.journal | Cells | en_US |
| bordeaux.page | 2582 | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 16 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.team | Relations glie-neurone | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Università Politecnica delle Marche | en_US |
| hal.identifier | hal-03860022 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-11-18T13:37:54Z | |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cells&rft.date=2022-08-19&rft.volume=11&rft.issue=16&rft.spage=2582&rft.epage=2582&rft.eissn=2073-4409&rft.issn=2073-4409&rft.au=PAGANO%20ZOTTOLA,%20Antonio%20C.&SEVERI,%20Ilenia&CANNICH,%20Astrid&CIOFI,%20Philippe&COTA,%20Daniela&rft.genre=article |
