Emerging opportunities in bioconjugates of Elastin-like polypeptides with synthetic or natural polymers.
| dc.rights.license | embargo | en_US |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sébastien | |
| dc.date.accessioned | 2022-11-17T14:58:19Z | |
| dc.date.available | 2022-11-17T14:58:19Z | |
| dc.date.issued | 2022-10-30 | |
| dc.identifier.issn | 1872-8294 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170313 | |
| dc.description.abstractEn | Nature is an everlasting source of inspiration for chemical and polymer scientists seeking to develop ever more innovative materials with greater performances. Natural structural proteins are particularly scrutinized to design biomimetic materials. Often characterized by repeat peptide sequences, that together interact by inter- and intramolecular interactions and form a 3D skeleton, they contribute to the mechanical properties of individual cells, tissues, organs, and whole organisms. (Numata, K. Polymer Journal 2020, 52, 1043-1056) Among them elastin, and its main repeat sequences, have been a source of intense studies for more than 50 years resulting in the specific research field dedicated to elastin-like polypeptides (ELPs). These are currently widely investigated in different applications, namely protein purification, tissue engineering, and drug delivery, and some technologies based on ELPs are currently explored by several start-up companies. In the present review, we have summarized pioneering contributions on ELPs, progress made in their genetic engineering, and understanding of their thermal behavior and self-assembly properties. Considered as intrinsically disordered protein polymers, we have finally focused on the works where ELPs have been conjugated to other synthetic macromolecules as covalent hybrid, statistical, graft, or block copolymers, highlighting the huge opportunities that have still not been explored so far. | |
| dc.description.sponsorship | Développement de squelettes polypeptidiques recombinants pour la synthèse de glycoconjugués multivalents parfaitement définis - ANR-15-CE07-0002 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.subject.en | Elastin-like polypeptides | |
| dc.subject.en | Stimuli-responsive polymers | |
| dc.subject.en | Lower solubility critical temperature | |
| dc.subject.en | Self-assembly | |
| dc.subject.en | Hybrid protein-polymer conjugates | |
| dc.subject.en | Hybrid ELP-polymer bioconjugates | |
| dc.subject.en | Biomimetic materials | |
| dc.subject.en | Biomaterials | |
| dc.subject.en | Tissue engineering | |
| dc.subject.en | Surface coating | |
| dc.subject.en | Drug delivery systems | |
| dc.title.en | Emerging opportunities in bioconjugates of Elastin-like polypeptides with synthetic or natural polymers. | |
| dc.title.alternative | Adv Drug Deliv Rev | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.addr.2022.114589 | en_US |
| dc.subject.hal | Chimie/Polymères | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| dc.identifier.pubmed | 36323382 | en_US |
| bordeaux.journal | Advanced Drug Delivery Reviews | en_US |
| bordeaux.page | 114589 | en_US |
| bordeaux.volume | 191 | en_US |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03858114 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-11-17T14:58:22Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY-NC-SA | en_US |
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