Mostrar el registro sencillo del ítem

dc.rights.licenseopenen_US
dc.contributor.authorKULIK, Shanna D.
dc.contributor.authorNAUTA, Ilse M.
dc.contributor.authorTEWARIE, Prejaas
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOUBIYR, Ismail
dc.contributor.authorVAN DELLEN, Edwin
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.contributor.authorMEIJER, Kim A.
dc.contributor.authorDE JONG, Brigit A.
dc.contributor.authorSTAM, Cornelis J.
dc.contributor.authorHILLEBRAND, Arjan
dc.contributor.authorGEURTS, Jeroen J.G.
dc.contributor.authorDOUW, Linda
dc.contributor.authorSCHOONHEIM, Menno M.
dc.date.accessioned2022-11-10T15:59:47Z
dc.date.available2022-11-10T15:59:47Z
dc.date.issued2022-06-01
dc.identifier.issn2472-1751en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170247
dc.description.abstractEnMultiple sclerosis (MS) features extensive connectivity changes, but how structural and functional connectivity relate, and whether this relation could be a useful biomarker for cognitive impairment in MS is unclear. This study included 79 MS patients and 40 healthy controls (HCs). Patients were classified as cognitively impaired (CI) or cognitively preserved (CP). Structural connectivity was determined using diffusion MRI and functional connectivity using resting-state magnetoencephalography (MEG) data (theta, alpha1, and alpha2 bands). Structure-function coupling was assessed by correlating modalities, and further explored in frequency bands that significantly correlated with whole-brain structural connectivity. Functional correlates of short-and long-range structural connections (based on tract length) were then specifically assessed. Receiving operating curve analyses were performed on coupling values to identify biomarker potential. Only the theta band showed significant correlations between whole-brain structural and functional connectivity (rho = −0.26, p = 0.023, only in MS). Long-range structure-function coupling was stronger in CI patients compared to HCs ( p = 0.005). Short-range coupling showed no group differences. Structure-function coupling was not a significant classifier of cognitive impairment for any tract length (short-range area under the curve (AUC) = 0.498, p = 0.976, long-range AUC = 0.611, p = 0.095). Long-range structure-function coupling was stronger in CI MS compared to HCs, but more research is needed to further explore this measure as biomarkers in MS. © MIT Press Journals. All rights reserved.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enBiomarkers
dc.subject.enBrain Mapping
dc.subject.enDiffusion Tensor Imaging
dc.subject.enMagnetoencephalography
dc.subject.enCognition
dc.subject.enCognitive Impairment
dc.subject.enCognitively Impaired
dc.subject.enFunctional Connectivity
dc.subject.enHealthy Controls
dc.subject.enLong-Range Structures
dc.subject.enMultiple Sclerosis
dc.subject.enStructural Connectivity
dc.subject.enStructure Functions
dc.subject.enWhole Brains
dc.subject.enMagnetic Resonance Imaging
dc.title.enStructure-function coupling as a correlate and potential biomarker of cognitive impairment in multiple sclerosis
dc.title.alternativeNetw Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1162/netn_a_00226en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed35733434en_US
bordeaux.journalNetwork Neuroscienceen_US
bordeaux.page339-356en_US
bordeaux.volume6en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamRelations glie-neuroneen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03847718
hal.version1
hal.date.transferred2022-11-10T16:00:15Z
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Network%20Neuroscience&rft.date=2022-06-01&rft.volume=6&rft.issue=2&rft.spage=339-356&rft.epage=339-356&rft.eissn=2472-1751&rft.issn=2472-1751&rft.au=KULIK,%20Shanna%20D.&NAUTA,%20Ilse%20M.&TEWARIE,%20Prejaas&KOUBIYR,%20Ismail&VAN%20DELLEN,%20Edwin&rft.genre=article


Archivos en el ítem

Thumbnail
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem