Mostrar el registro sencillo del ítem
Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission
| dc.rights.license | open | en_US |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | PUPIER, Emilie | |
| dc.contributor.author | SANTOS, Alicia | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | ETCHAMENDY, Nicole | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | LAVIELLE, Aurelie | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | FERRIERE, Amandine | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARIGHETTO, Aline | |
| dc.contributor.author | RESMINI, Eugenia | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| dc.contributor.author | WEBB, Susan M. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | TABARIN, Antoine | |
| dc.date.accessioned | 2022-11-09T10:56:30Z | |
| dc.date.available | 2022-11-09T10:56:30Z | |
| dc.date.issued | 2022-08-08 | |
| dc.identifier.issn | 1664-2392 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170240 | |
| dc.description.abstractEn | Context: Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD). Persistent comorbidities and treatment modalities may account for cognitive impairments. Therefore, the role of hypercortisolism per se on cognitive sequelae remains debatable. Objective: To investigate whether memory and QoL are impaired after long-term remission of CD in patients with no confounding comorbidity. Design and Setting: Cross-sectional case-control study in two tertiary referral centers Patients: 25 patients (44.5 ± 2.4 years) in remission from CD for 102.7 ± 19.3 Mo and 25 well-matched controls, without comorbidity or treatment liable to impair cognition. Main Outcome Measure(s): Hippocampus- and prefrontal cortex-dependent memory, including memory flexibility and working memory, were investigated using multiple tests including sensitive locally-developed computerized tasks. Depression and anxiety were evaluated with the MADRS and HADS questionnaires. QoL was evaluated with the SF-36 and CushingQoL questionnaires. The intensity of CD was assessed using mean urinary free cortisol and a score for clinical symptoms. Results: CD patients displayed similar performance to controls in all cognitive tests. In contrast, despite the absence of depression and a minimal residual clinical Cushing score, patients had worse QoL. Most of the SF36 subscales and the CushingQoL score were negatively associated only with the duration of exposure to hypercortisolism (p≤ 0.01 to 0.001). Conclusions: Persistent comorbidities can be a primary cause of long-lasting cognitive impairment and should be actively treated. Persistently altered QoL may reflect irreversible effects of hypercortisolism, highlighting the need to reduce its duration. Clinical Trial Registration number: https://clinicaltrials.gov, identifier NCT02603653. Copyright © 2022 Pupier, Santos, Etchamendy, Lavielle, Ferriere, Marighetto, Resmini, Cota, Webb and Tabarin. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Hemoglobin A1c | |
| dc.subject.en | Hydrocortisone | |
| dc.subject.en | Adrenal Insufficiency | |
| dc.subject.en | Adult | |
| dc.subject.en | Anxiety | |
| dc.subject.en | Article | |
| dc.subject.en | Body Mass | |
| dc.subject.en | Cognition | |
| dc.subject.en | Cognitive Defect | |
| dc.subject.en | Comorbidity | |
| dc.subject.en | Controlled Study | |
| dc.subject.en | Cross-Sectional Study | |
| dc.subject.en | Cushing Disease | |
| dc.subject.en | Dexamethasone Suppression Test | |
| dc.subject.en | Diastolic Blood Pressure | |
| dc.subject.en | Ecchymosis | |
| dc.subject.en | Female | |
| dc.subject.en | Hippocampus | |
| dc.subject.en | Hospital Anxiety And Depression Scale | |
| dc.subject.en | Human | |
| dc.subject.en | Hypercortisolism | |
| dc.subject.en | Hypertension | |
| dc.subject.en | Hypothyroidism | |
| dc.subject.en | Major Clinical Study | |
| dc.subject.en | Male | |
| dc.subject.en | Montgomery Asberg Depression Rating Scale | |
| dc.subject.en | Neuropsychological Test | |
| dc.subject.en | Obesity | |
| dc.subject.en | Quality Of Life | |
| dc.subject.en | Rey Auditory Verbal Learning Test | |
| dc.subject.en | Rey Osterrieth Complex Figure Test | |
| dc.subject.en | Short Form 36 | |
| dc.subject.en | Systolic Blood Pressure | |
| dc.subject.en | Tertiary Care Center | |
| dc.subject.en | Visual Memory | |
| dc.subject.en | Wechsler Memory Scale | |
| dc.subject.en | Working Memory | |
| dc.title.en | Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission | |
| dc.title.alternative | Front Endocrinol. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fendo.2022.934347 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 36004342 | en_US |
| bordeaux.journal | Frontiers in Endocrinology | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Physiopathologie de la mémoire déclarative | en_US |
| bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03845130 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-11-09T10:56:38Z | |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Endocrinology&rft.date=2022-08-08&rft.volume=13&rft.eissn=1664-2392&rft.issn=1664-2392&rft.au=PUPIER,%20Emilie&SANTOS,%20Alicia&ETCHAMENDY,%20Nicole&LAVIELLE,%20Aurelie&FERRIERE,%20Amandine&rft.genre=article |
