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Risk factors for admission to the pediatric critical care unit among children hospitalized with COVID-19 in France
| dc.rights.license | open | en_US |
| dc.contributor.author | PREVOST, Blandine | |
| dc.contributor.author | RETBI, Aurelia | |
| dc.contributor.author | BINDER-FOUCARD, Florence | |
| dc.contributor.author | BORDE, Aurelie | |
| dc.contributor.author | BRUANDET, Amelie | |
| dc.contributor.author | CORVOL, Harriet | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GILLERON, Veronique | |
| dc.contributor.author | LE BOURHIS-ZAIMI, Maggie | |
| dc.contributor.author | LENNE, Xavier | |
| dc.contributor.author | MULLER, Joris | |
| dc.contributor.author | OUATTARA, Eric | |
| dc.contributor.author | SEGURET, Fabienne | |
| dc.contributor.author | TRAN BA LOC, Pierre | |
| dc.contributor.author | TEZENAS DU MONTCEL, Sophie | |
| dc.date.accessioned | 2022-11-02T10:12:21Z | |
| dc.date.available | 2022-11-02T10:12:21Z | |
| dc.date.issued | 2022-09-07 | |
| dc.identifier.issn | 2296-2360 (Print) 2296-2360 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170188 | |
| dc.description.abstractEn | BACKGROUND: COVID-19 infection is less severe among children than among adults; however, some patients require hospitalization and even critical care. Using data from the French national medico-administrative database, we estimated the risk factors for critical care unit (CCU) admissions among pediatric COVID-19 hospitalizations, the number and characteristics of the cases during the successive waves from January 2020 to August 2021 and described death cases. METHODS: We included all children (age < 18) hospitalized with COVID-19 between January 1st, 2020, and August 31st, 2021. Follow-up was until September 30th, 2021 (discharge or death). Contiguous hospital stays were gathered in "care sequences." Four epidemic waves were considered (cut off dates: August 11th 2020, January 1st 2021, and July 4th 2021). We excluded asymptomatic COVID-19 cases, post-COVID-19 diseases, and 1-day-long sequences (except death cases). Risk factors for CCU admission were assessed with a univariable and a multivariable logistic regression model in the entire sample and stratified by age, whether younger than 2. RESULTS: We included 7,485 patients, of whom 1988 (26.6%) were admitted to the CCU. Risk factors for admission to the CCU were being younger than 7 days [OR: 3.71 95% CI (2.56-5.39)], being between 2 and 9 years old [1.19 (1.00-1.41)], pediatric multisystem inflammatory syndrome (PIMS) [7.17 (5.97-8.6)] and respiratory forms [1.26 (1.12-1.41)], and having at least one underlying condition [2.66 (2.36-3.01)]. Among hospitalized children younger than 2 years old, prematurity was a risk factor for CCU admission [1.89 (1.47-2.43)]. The CCU admission rate gradually decreased over the waves (from 31.0 to 17.8%). There were 32 (0.4%) deaths, of which the median age was 6 years (IQR: 177 days-15.5 years). CONCLUSION: Some children need to be more particularly protected from a severe evolution: newborns younger than 7 days old, children aged from 2 to 13 years who are more at risk of PIMS forms and patients with at least one underlying medical condition. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | COVID-19 | |
| dc.subject.en | SARS-CoV-2 | |
| dc.subject.en | Children | |
| dc.subject.en | Critical care | |
| dc.subject.en | Hospitalization | |
| dc.title.en | Risk factors for admission to the pediatric critical care unit among children hospitalized with COVID-19 in France | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fped.2022.975826 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36160797 | en_US |
| bordeaux.journal | Frontiers in Pediatrics | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PHARES_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03774138 | |
| hal.version | 1 | |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Pediatrics&rft.date=2022-09-07&rft.volume=10&rft.eissn=2296-2360%20(Print)%202296-2360%20(Linking)&rft.issn=2296-2360%20(Print)%202296-2360%20(Linking)&rft.au=PREVOST,%20Blandine&RETBI,%20Aurelia&BINDER-FOUCARD,%20Florence&BORDE,%20Aurelie&BRUANDET,%20Amelie&rft.genre=article |
