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A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk

dc.rights.licenseopenen_US
dc.contributor.authorMAYEN, Ana-Lucia
dc.contributor.authorVIALLON, Vivian
dc.contributor.authorBOTTERI, Edoardo
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
dc.contributor.authorBAGNARDI, Vincenzo
dc.contributor.authorBATISTA, Veronica
dc.contributor.authorCROSS, Amanda J.
dc.contributor.authorLAOUALI, Nasser
dc.contributor.authorMACDONALD, Conor J.
dc.contributor.authorSEVERI, Gianluca
dc.contributor.authorKATZKE, Verena
dc.contributor.authorBERGMANN, Manuela M
dc.contributor.authorSCHULZE, Mattias B.
dc.contributor.authorTJONNELAND, Anne
dc.contributor.authorERIKSEN, Anne Kirstine
dc.contributor.authorDAHM, Christina C.
dc.contributor.authorANTONIUSSEN, Christian S.
dc.contributor.authorJAKSZYN, Paula
dc.contributor.authorSANCHEZ, Maria-Jose
dc.contributor.authorAMIANO, Pilar
dc.contributor.authorCOLORADO-YOHAR, Sandra M
dc.contributor.authorARDANAZ, Eva
dc.contributor.authorTRAVIS, Ruth
dc.contributor.authorPALLI, Domenico
dc.contributor.authorSABINA, Sieri
dc.contributor.authorTUMINO, Rosario
dc.contributor.authorRICCERI, Fulvio
dc.contributor.authorPANICO, Salvatore
dc.contributor.authorBUENO-DE-MESQUITA, Bas
dc.contributor.authorDERKSEN, Jeroen W. G.
dc.contributor.authorSONESTEDT, Emily
dc.contributor.authorWINKVIST, Anna
dc.contributor.authorHARLID, Sophia
dc.contributor.authorBRAATEN, Tonje
dc.contributor.authorGRAM, Inger Torhild
dc.contributor.authorLUKIC, Marko
dc.contributor.authorJENAB, Mazda
dc.contributor.authorRIBOLI, Elio
dc.contributor.authorFREISLING, Heinz
dc.contributor.authorWEIDERPASS, Elisabete
dc.contributor.authorGUNTER, Marc J.
dc.contributor.authorFERRARI, Pietro
dc.date.accessioned2022-11-02T09:25:15Z
dc.date.available2022-11-02T09:25:15Z
dc.date.issued2022-09-05
dc.identifier.issn1573-7284 (Electronic) 0393-2990 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170185
dc.description.abstractEnBACKGROUND: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. OBJECTIVE: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. METHODS: Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory profiles of alcohol intake, assessed at ages 20, 30, 40, 50 years, at baseline and during follow-up, were estimated using latent class mixed models and related to CRC risk, including 407,605 participants and 5,008 incident CRC cases. RESULTS: Mean age at baseline was 50.2 years and the follow-up assessment occurred on average 7.1 years later. Compared to stable intake, a 12 g/day increase in alcohol intake during follow-up was positively associated with CRC risk (HR = 1.15, 95%CI 1.04, 1.25), while a 12 g/day reduction was inversely associated with CRC risk (HR = 0.86, 95%CI 0.78, 0.95). Trajectory analysis showed that compared to low alcohol intake, men who increased their alcohol intake from early- to mid- and late-adulthood by up to 30 g/day on average had significantly increased CRC risk (HR = 1.24; 95%CI 1.08, 1.42), while no associations were observed in women. Results were consistent by anatomical subsite. CONCLUSIONS: Increasing alcohol intake during mid-to-late adulthood raised CRC risk, while reduction lowered risk.
dc.language.isoENen_US
dc.subject.enColorectal cancer
dc.subject.enAlcohol change
dc.subject.enAlcohol intake
dc.subject.enLongitudinal exposure
dc.subject.enTrajectory profile analysis
dc.subject.enLatent class mixed models
dc.title.enA longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10654-022-00900-6en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36063305en_US
bordeaux.journalEuropean Journal of Epidemiologyen_US
bordeaux.page915-929en_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDSchool of Public Health, Imperial College Londonen_US
bordeaux.identifier.funderIDDanish Cancer Society Research Centeren_US
bordeaux.identifier.funderIDLigue Contre le Canceren_US
bordeaux.identifier.funderIDInstitut Gustave-Roussyen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDMedical Research Councilen_US
bordeaux.identifier.funderIDCancer Research UKen_US
bordeaux.identifier.funderIDWorld Cancer Research Funden_US
hal.identifierhal-03836403
hal.version1
hal.date.transferred2022-11-02T09:25:27Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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