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Impact of the COVID-19 pandemic and its control measures on cardiovascular and antidiabetic drugs use in France in 2020: a nationwide repeated cohort study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHIEU, Clement
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPAMBRUN, Elodie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBENARD-LARIBIERE, Anne
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNOIZE, Pernelle
dc.contributor.authorFAILLIE, Jean-Luc
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBEZIN, Julien
ORCID: 0000-0002-2568-1928
IDREF: 181595710
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPARIENTE, Antoine
IDREF: 13395711X
dc.date.accessioned2022-11-02T09:15:43Z
dc.date.available2022-11-02T09:15:43Z
dc.date.issued2022-09-21
dc.identifier.issn1573-7284 (Electronic) 0393-2990 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/170184
dc.description.abstractEnSince pandemic start, patients may have faced difficulties in accessing to care and treatment. This study aimed at assessing the impact of COVID-19 pandemic and its control measures on the use of drugs indicated in cardiovascular prevention and diabetes mellitus in France. From 09/17/2018 to 09/20/2020, a repeated cohort analysis was performed using the French nationwide health insurance databases. The pandemic impact was assessed using time-series analyses and unobserved components model for the weekly number of patients with (i) drug dispensing, (ii) ongoing treatment, (iii) treatment initiation, (iv) treatment disruption. Overall, 14,822,132 patients with cardiovascular drug dispensings and 3,231,618 with antidiabetic ones were identified. After a sharp spike in the amount of dispensings in the week the first national lockdown was announced, the period was marked by decreased levels and trends. Altogether, the estimated impact of the pandemic on dispensings appeared limited over the lockdown period (1-3% lack in dispensings). During lockdown, the weekly numbers of treatment disruptions remained stable whereas a significant decrease in treatment initiations was observed for almost all drug classes (e.g. β-blockers initiations: - 8.9%). Conversely, the post-lockdown period showed increases in treatment disruptions especially for antihypertensive and lipid lowering drugs (e.g. statins disruptions: + 4.9%). The pandemic and associated measures had a significant impact on cardiovascular and antidiabetic drugs use in France, mostly consisting in decreases of treatment initiations over lockdown and increases in treatment disruptions afterwards. Both could result in increased morbimortality that remains to be assessed.
dc.language.isoENen_US
dc.subject.enPharmacoepidemiology
dc.subject.enCohort study
dc.subject.enLockdown
dc.subject.enCoronavirus
dc.subject.enCOVID-19
dc.title.enImpact of the COVID-19 pandemic and its control measures on cardiovascular and antidiabetic drugs use in France in 2020: a nationwide repeated cohort study
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10654-022-00912-2en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36129659en_US
bordeaux.journalEuropean Journal of Epidemiologyen_US
bordeaux.page1-11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Sécurité du Médicament et des Produits de Santéen_US
hal.identifierhal-03836387
hal.version1
hal.date.transferred2022-11-02T09:15:45Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Epidemiology&rft.date=2022-09-21&rft.spage=1-11&rft.epage=1-11&rft.eissn=1573-7284%20(Electronic)%200393-2990%20(Linking)&rft.issn=1573-7284%20(Electronic)%200393-2990%20(Linking)&rft.au=MATHIEU,%20Clement&PAMBRUN,%20Elodie&BENARD-LARIBIERE,%20Anne&NOIZE,%20Pernelle&FAILLIE,%20Jean-Luc&rft.genre=article


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