Microperimetry to predict disease progression in eyes at high risk of age-related macular degeneration disease: The PREVISION study
| dc.rights.license | open | en_US |
| dc.contributor.author | KODJIKIAN, Laurent | |
| dc.contributor.author | CREUZOT-GARCHER, Catherine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535 IDREF: 028739272 | |
| dc.contributor.author | TADAYONI, Ramin | |
| dc.contributor.author | DELAFOY, Ivan | |
| dc.contributor.author | LEAL, Cecilia | |
| dc.contributor.author | BERNARD, Lorraine | |
| dc.contributor.author | DECULLIER, Evelyne | |
| dc.contributor.author | HUOT, Laure | |
| dc.contributor.author | MATHIS, Thibaud | |
| dc.date.accessioned | 2022-10-31T14:49:18Z | |
| dc.date.available | 2022-10-31T14:49:18Z | |
| dc.date.issued | 2023-03 | |
| dc.identifier.issn | 1755-375x | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170180 | |
| dc.description.abstractEn | PURPOSE: The aim of the present study was to determine whether microperimetric parameters could predict the progression of an eye at high risk of age-related macular degeneration (AMD) at 24 months. METHODS: We conducted a multicentric prospective non-comparative open-label study including patients with one eye in stage 4 of the Age-Related Eye Disease Study Group (AREDS) classification, and the other eye in AREDS stage 3 (study eye). A microperimetry examination (MAIA™, CenterVue, Padova, Italy) was performed at baseline and every 6 months during the 2-year follow-up. At the end of the follow-up, each study eye was classified as 'progressive' (i.e. AREDS stage 4) or 'non-progressive' (i.e. AREDS stage 3). RESULTS: A total of 147 patients were analysed, of which 30.6% progressed from AREDS stage 3 to stage 4. The microperimetry criterion 'mean retinal sensitivity' was significantly different at baseline between non-progressive and progressive eyes (p = 0.022), with lower values for the latter. With a threshold for mean retinal sensitivity set at 24.7 dB, diagnostic sensitivity was 80% [95%CI (65.4-90.4)], specificity was 30.4% [95%CI (21.7-40.3)], positive predictive value was 33.6% [95%CI (24.8-43.4)], and negative predictive value was 77.5% [95%CI (61.5-89.2)]. In the multivariate analysis including microperimetric parameters and other routine ophthalmologic examinations, mean retinal sensitivity was the only predictive parameter statistically associated with progression (p = 0.0004). CONCLUSIONS: Our findings are encouraging as regards the use of microperimetry, and mean retinal sensitivity value in particular, to predict the 2-year risk of progression to AREDS stage 4 eye. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Age-related macular degeneration | |
| dc.subject.en | AREDS | |
| dc.subject.en | Biomarker | |
| dc.subject.en | Microperimetry | |
| dc.subject.en | Prediction | |
| dc.subject.en | Progression | |
| dc.title.en | Microperimetry to predict disease progression in eyes at high risk of age-related macular degeneration disease: The PREVISION study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/aos.15260 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36120870 | en_US |
| bordeaux.journal | Acta Ophthalmologica | en_US |
| bordeaux.page | e135-e142 | |
| bordeaux.volume | 101 | |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 2 | |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Novartis | en_US |
| hal.identifier | hal-03813690 | |
| hal.version | 1 | |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Acta%20Ophthalmologica&rft.date=2023-03&rft.volume=101&rft.issue=2&rft.spage=e135-e142&rft.epage=e135-e142&rft.eissn=1755-375x&rft.issn=1755-375x&rft.au=KODJIKIAN,%20Laurent&CREUZOT-GARCHER,%20Catherine&KOROBELNIK,%20Jean-Francois&TADAYONI,%20Ramin&DELAFOY,%20Ivan&rft.genre=article |
