Impaired Facial Emotion Recognition and Gaze Direction Detection in Mild Alzheimer's Disease: Results from the PACO Study
| dc.rights.license | open | en_US |
| dc.contributor.author | COMON, Martin | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ROUCH, Isabelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | EDJOLO, Arlette | |
| dc.contributor.author | PADOVAN, Catherine | |
| dc.contributor.author | KROLAK-SALMON, Pierre | |
| dc.contributor.author | DOREY, Jean-Michel | |
| dc.date.accessioned | 2022-10-31T10:48:53Z | |
| dc.date.available | 2022-10-31T10:48:53Z | |
| dc.date.issued | 2022-09-01 | |
| dc.identifier.issn | 1875-8908 (Electronic) 1387-2877 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/170171 | |
| dc.description.abstractEn | BACKGROUND: Facial emotion recognition (FER) and gaze direction (GD) identification are core components of social cognition, possibly impaired in many psychiatric or neurological conditions. Regarding Alzheimer's disease (AD), current knowledge is controversial. OBJECTIVE: The aim of this study was to explore FER and GD identification in mild AD compared to healthy controls. METHODS: 180 participants with mild AD drawn from the PACO study and 74 healthy elderly controls were enrolled. Participants were asked to complete three socio-cognitive tasks: face sex identification, recognition of facial emotions (fear, happiness, anger, disgust) expressed at different intensities, and GD discrimination. Multivariate analyses were conducted to compare AD participants and healthy controls. RESULTS: Sex recognition was preserved. GD determination for subtle deviations was impaired in AD. Recognition of prototypically expressed facial emotions was preserved while recognition of degraded facial emotions was impacted in AD participants compared to controls. Use of multivariate analysis suggested significant alteration of low-expressed fear and disgust recognition in the AD group. CONCLUSION: Our results showed emotion recognition and GD identification in patients with early-stage AD compared to elderly controls. These impairments could be the object of specific therapeutic interventions such as social cognition remediation or raising awareness of primary caregivers to improve the quality of life of patients with early AD. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Alzheimer’s disease | |
| dc.subject.en | Elderly | |
| dc.subject.en | Facial emotion recognition | |
| dc.subject.en | Social cognition | |
| dc.title.en | Impaired Facial Emotion Recognition and Gaze Direction Detection in Mild Alzheimer's Disease: Results from the PACO Study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3233/jad-220401 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 36057821 | en_US |
| bordeaux.journal | Journal of Alzheimer's Disease | en_US |
| bordeaux.page | 1427-1437 | en_US |
| bordeaux.volume | 89 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ACTIVE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03835009 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-10-31T10:48:55Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Alzheimer's%20Disease&rft.date=2022-09-01&rft.volume=89&rft.issue=4&rft.spage=1427-1437&rft.epage=1427-1437&rft.eissn=1875-8908%20(Electronic)%201387-2877%20(Linking)&rft.issn=1875-8908%20(Electronic)%201387-2877%20(Linking)&rft.au=COMON,%20Martin&ROUCH,%20Isabelle&EDJOLO,%20Arlette&PADOVAN,%20Catherine&KROLAK-SALMON,%20Pierre&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||